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Interaction between dendritic cells and nerve fibres in lymphoid organs after oral scrapie exposure. | LitMetric

AI Article Synopsis

  • Transmissible spongiform encephalopathies (TSEs) are caused by an infectious agent called PrPsc, which is an abnormal version of a prion protein that first accumulates in lymphoid organs.
  • Research using confocal microscopy on mice examined how this agent moves from lymphoid organs to the nervous system, focusing on structures like Peyer's patches, mesenteric lymph nodes, and the spleen.
  • The study found that while follicular dendritic cells (FDCs) did not have nerve connections, dendritic cells (DCs) were in contact with nerve fibers, suggesting they might play a role in how prions invade the nervous system.

Article Abstract

In transmissible spongiform encephalopathies (TSEs), the infectious agent, called PrPsc, an abnormal isoform of the cellular prion protein, accumulates and replicates in lymphoid organs before affecting the nervous system. To clarify the cellular requirements for the neuroinvasion of the scrapie agent from the lymphoid organs to the central nervous system, we have studied, by confocal microscopy, the innervations within Peyer's patches, mesenteric lymph nodes and the spleen of mice in physiological conditions and after oral exposure to prion. Contacts between nerve fibres and PrPsc-associated cells, dendritic cells (DCs) and follicular dendritic cells (FDCs), were evaluated in preclinical prion-infected mice. Using a double immunolabelling strategy, we demonstrated the lack of innervation of PrPsc-accumulating cells (FDCs). Contacts between nerve fibers and PrPsc-propagating cells (DCs) were detected in T-cell zones and cell-trafficking areas. This supports, for the first time, the possible implication of dendritic cells in the prion neuroinvasion process.

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Source
http://dx.doi.org/10.1007/s00428-007-0476-6DOI Listing

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