Aim: Can monovoxel magnetic resonance spectroscopy (MRS) reliably follow tumour progression in low-grade glioma?
Materials And Methods: 21 patients with low-grade glioma underwent at least 3 MRS.
Results: For progression from a grade II to grade III tumour, a sensitivity of 57.1% and specificity of 60% were observed, with a positive predictive value (PPV) of 48.8% and a negative predictive value (NPV) of 54.5%. For progression under treatment, we obtained a sensitivity of 57.1% by N-acetylaspartate (NAA)/choline (Cho) and myoinositol/creatine (Cr) and a specificity of 100% by Cho/Cr and lipids, with a PPV of 80% and a NPV of 63.6%.
Conclusion: We found that NAA/Cho is the best marker of tumour progression before therapy, with a sensitivity of 53.9%. For the therapeutic response, sensitivity was only 28.2%.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000107940 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A correlation between Magnetic Resonance Spectroscopy (1-H MRS) and the neurodevelopment of two-year-olds born preterm in an EPIRMEX cohort study.
Front Pediatr
August 2022
Department of Neonatal Medicine, Assistance Publique Hopitaux de Marseille, Marseille, France.
Background: Preterm infants are at risk of neurodevelopmental impairments. At present, proton magnetic resonance spectroscopy (1H-MRS) is currently used to evaluate brain metabolites in asphyxiated term infants. The purpose of this study was to identify in the preterm EPIRMEX cohort any correlations between (1H-MRS) metabolites ratio at term equivalent age (TEA) and neurodevelopmental outcomes at 2 years.
View Article and Find Full Text PDFFID modulus: a simple and efficient technique to phase and align MR spectra.
MAGMA
April 2014
Aix-Marseille Université, CNRS, CRMBM UMR 7339, 13385, Marseille, France,
Object: The post-processing of MR spectroscopic data requires several steps more or less easy to automate, including the phase correction and the chemical shift assignment. First, since the absolute phase is unknown, one of the difficulties the MR spectroscopist has to face is the determination of the correct phase correction. When only a few spectra have to be processed, this is usually performed manually.
View Article and Find Full Text PDFRespiratory chain deficiencies.
Handb Clin Neurol
March 2014
Department of Pediatric Metabolism, Reference Center, Hôpital Necker-Enfants Malades, and Université Paris Descartes, Paris, France. Electronic address:
Mitochondrial functions are intimately associated with neurological symptoms. Various clinical and biological features are suggestive of energy depletion diseases, such as Leigh syndrome, Alpers syndrome, epilepsy (including myoclonic seizures and status epilepticus), stroke-like episodes, and acute cerebellar ataxia with high lactate peaks on magnetic resonance spectroscopy. Magnetic resonance imaging (MRI) discloses abnormalities in over 90% of the cases presenting with neurological symptoms.
View Article and Find Full Text PDFMonovoxel 1H magnetic resonance spectroscopy in the progression of gliomas.
Eur Neurol
January 2008
Department of Radiology, Geneva University Hospital, Geneva, Switzerland.
Aim: Can monovoxel magnetic resonance spectroscopy (MRS) reliably follow tumour progression in low-grade glioma?
Materials And Methods: 21 patients with low-grade glioma underwent at least 3 MRS.
Results: For progression from a grade II to grade III tumour, a sensitivity of 57.1% and specificity of 60% were observed, with a positive predictive value (PPV) of 48.
Accurate 1H tumor spectra quantification from acquisitions without water suppression.
Magn Reson Imaging
November 2006
Institute for Neurological Research (FLENI), Buenos Aires, Argentina.
Monovoxel magnetic resonance spectroscopy (MRS) is a technique extensively used for the study of brain tumors in many imaging centers. However, given the fact that monovoxel spectrum quality depends upon voxel size, region of acquisition and the presence of metal and/or blood residue after surgery can make the comparison of MRS brain tumor spectra more difficult than that of other pathologies. This study was conducted in order to evaluate whether it is possible to predict in which cases a tumor spectrum will be quantifiable from acquisitions obtained without water suppression, allowing comparison to other spectra.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!