Dissatisfaction after total hip arthroplasty (THA) is linked to complications due to comorbitities, radiographic loosening, and poor prosthetic alignment. However, some patients have functional problems without obvious causes. This study elucidated soft tissue abnormalities that may lead to THA dysfunction and assessed the efficacy of customized physical therapeutic modalities. Seventy-eight THA patients complaining of poor functionality capabilities at 3 months after index THA were studied with a detailed physical examination and gait analysis with videotape, 3-dimensional gait studies, and isokinetic strength assessments used when necessary. Patients had muscle weakness (57), muscle tightness (32), limb length differences (11), and/or limb malalignment (10). Treatment protocols included physical therapy, electrical stimulation, shoe lifts, intramuscular botulinum, and corticosteroid injections. At 61-month mean follow-up, 73 (94%) patients had good to excellent clinical outcomes. Patient satisfaction averaged 8.7 of 10 possible points. These results suggest that various assessments and 3-dimensional gait studies are valuable tools in identifying problems after THA and help direct customized rehabilitation modalities.
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http://dx.doi.org/10.1016/j.arth.2007.04.025 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016.
Posttranslational modifications (PTMs) of proteins play critical roles in regulating many cellular events. Antibodies targeting site-specific PTMs are essential tools for detecting and enriching PTMs at sites of interest. However, fundamental difficulties in molecular recognition of both PTM and surrounding peptide sequence have hindered the efficient generation of highly sequence-specific anti-PTM antibodies.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Neonatology/Neonatal Intensive Care Unit, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Crete, Greece.
Preterm births constitute a major public health issue and a chronic, cross-generational condition globally. Psychological and biological factors interact in a way that women from low socio-economic status (SES) are disproportionally affected by preterm delivery and at increased risk for the development of perinatal mental health problems. Low SES constitutes one of the most evident contributors to poor neurodevelopment of preterm infants.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Preventive Medicine, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.
Background: Despite the rising prevalence of common mental symptoms, information is scarce on how health workers make sense of symptoms of mental disorders and perceive a link with inadequate water, sanitation, and hygiene (WASH) as work stressors to understand causation and produce useful knowledge for policy and professionals. Therefore, this study aimed to explore how health workers perceive the link between inadequate WASH and common mental symptoms (CMSs) at hospitals in central and southern Ethiopian regions.
Methods: We used an interpretive and descriptive phenomenological design guided by theoretical frameworks.
Medicine (Baltimore)
January 2025
School of Medical Laboratory Sciences, Faculty of Health Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.
Anemia is a worldwide public health problem and is associated with platelet disorders. The relationship between anemia and platelets is complex, with the association being either normal platelet count or thrombocytosis. Platelets are significantly decreased in patients with anemia, and thrombocytopenia has been documented in patients with severe anemia.
View Article and Find Full Text PDFWorking memory (WM) is an evolving concept. Our understanding of the neural functions that support WM develops iteratively alongside the approaches used to study it, and both can be profoundly shaped by available tools and prevailing theoretical paradigms. Here, the organizers of the 2024 Working Memory Symposium-inspired by this year's meeting-highlight current trends and looming questions in WM research.
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