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Comprehensive Cellular Senescence Evaluation to Aid Targeted Therapies.
Research (Wash D C)
January 2025
State Key Laboratory of Genetic Engineering, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, Center for Evolutionary Biology, Shanghai Engineering Research Center of Industrial Microorganisms, School of Life Sciences, Fudan University, Shanghai 200438, China.
Drug resistance to a single agent is common in cancer-targeted therapies, and rational drug combinations are a promising approach to overcome this challenge. Many Food and Drug Administration-approved drugs can induce cellular senescence, which possesses unique vulnerabilities and molecular signatures. However, there is limited analysis on the effect of the combination of cellular-senescence-inducing drugs and targeted therapy drugs.
View Article and Find Full Text PDFCan the Urban Lifestyle Impact on Children BMI and Healthy Sleep?
Am J Hum Biol
January 2025
Research Centre for Anthropology and Health, University of Coimbra, Coimbra, Portugal.
Objectives: This study aimed to (i) compare children's lifestyle by urbanization level and (ii) examine the association between children's body mass index (BMI) and the risk of having unhealthy sleep (American Academy of Pediatrics).
Methods: Eight thousand one hundred fifty-nine children (4124 females) aged 6-9 years were observed and classified as urban or nonurban. Height and weight were measured, and the BMI was calculated.
Measurement tools used to assess individual health assets among refugee populations: a scoping review.
Health Promot Int
January 2025
School of Public Health, Faculty of Health, University of Technology Sydney, Ultimo, New South Wales, 2007, Australia.
Forced migration is increasing globally, which has detrimental effects on the physical and mental health of refugees, who may face significant challenges accessing healthcare services. However, refugees also possess considerable strengths or assets that can protect against various health challenges. Identifying and strengthening the individual health assets of refugees is critical to promoting their health and mitigating these health challenges.
View Article and Find Full Text PDFSynergistic development of intangible cultural heritage and tourism industry: Empirical experiences from Jilin, China.
PLoS One
January 2025
Jilin Jianzhu University, Changchun, Jilin, China.
This study focuses on the Jilin region of China, conducting a multidimensional assessment of the current state of the synergistic development between Intangible Cultural Heritage (ICH) and the tourism industry in the area. The objective is to explore the issues surrounding the coordinated development of ICH and the tourism sector. The findings are as follows: 1) The overall coupling degree between the ICH and tourism systems in the Jilin region is 0.
View Article and Find Full Text PDFWarm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain bacteria, potentially causing sticky stool.
BMC Microbiol
January 2025
School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Background And Aims Of The Study: Fluctuations in environmental temperature and humidity significantly affect human physiology and disease manifestation. In the Lingnan region of China, high summer temperatures and humidity often cause symptoms like diminished appetite, sticky tongue coating, sticky stool, unsatisfactory defecation, lethargy, and joint heaviness. These are referred to as "Dampness Syndrome" in Traditional Chinese Medicine (TCM).
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