Utlrastructure and formation of lamellated inclusion bodies (LB) in N-dibutyl-nitrosamine-induced lung tumors in European hamsters are described. Two types of LBs are observed: one with cross-barred lamellae and one with concentric lamellae. Both types develop from lysosome-like dense bodies which are formed by the Golgi apparatus. More mature forms fuse with rough endoplasmic reticulum (RER). Mature LBs migrate to the cell surface, where their contents are extruded into the alveolar lumen by means of a merocrine secretion. The extruded lamellae give rise to the myelin figures and lattices that are reported to possess surfactant properties.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2032324 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Monostotic femoral Caffey disease masquerading as Ewing sarcoma.
BMJ Case Rep
September 2024
Department of Radiodiagnosis, All India Institute of Medical Sciences - Patna, Patna, Bihar, India.
Article Synopsis
- A baby had a rare condition called Caffey disease that caused swelling in their left thigh after getting vaccinated.
- Doctors did tests and saw that the baby didn’t have a real tumor, but rather a reaction in the bone.
- After some treatment, the baby got better and doctors noticed good changes in the bone during follow-up exams.
L-serine restored lysosomal failure in cells derived from patients with BPAN reducing iron accumulation with eliminating lipofuscin.
Free Radic Biol Med
August 2024
Neural Circuit Research Group, Korea Brain Research Institute, Daegu, South Korea. Electronic address:
Article Synopsis
- * Treatment with the iron chelator 2,2'-bipyridine (BIP) slightly reduced iron levels in the cytoplasm and mitochondria, but did not significantly improve lysosomal iron accumulation or levels of reactive oxygen species (ROS) related to oxidative stress in BPAN patient cells.
- * In contrast, l-serine treatment effectively reduced enlarged lysosomes, lowered iron accumulation, improved lysosomal activity by decreasing oxidized lipid levels, and diminished the
The // clade functions in Arabidopsis root suberization nonredundantly with the clade required for suberin lamellae.
Proc Natl Acad Sci U S A
May 2024
Department of Plant Molecular Biology, University of Lausanne, Lausanne CH-1015, Switzerland.
Lipid polymers such as cutin and suberin strengthen the diffusion barrier properties of the cell wall in specific cell types and are essential for water relations, mineral nutrition, and stress protection in plants. Land plant-specific glycerol-3-phosphate acyltransferases (GPATs) of different clades are central players in cutin and suberin monomer biosynthesis. Here, we show that the // clade in , which is known to mediate cutin formation, is also required for developmentally regulated root suberization, in addition to the established roles of in suberization.
View Article and Find Full Text PDFNovel Digenic Variants in and Causing X-Linked Alport Syndrome: A Case Report.
Case Rep Nephrol Dial
January 2024
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Introduction: Alport syndrome (AS) is a hereditary, progressive kidney disease characterized by structural abnormalities and dysfunction of the glomerular basement membrane (GBM). AS is classified as X-linked, autosomal, and digenic. The number of cases of digenic AS has increased, but the genotype-phenotype correlation of patient with digenic AS is still unclear.
View Article and Find Full Text PDFX-linked Alport Syndrome with Type IV Collagen α5 Chain Staining Revealing Normal Expression in the Glomerular Basement Membrane and Negative on Bowman's Capsule and Distal Tubular Basement Membrane: A Case Report.
Tohoku J Exp Med
September 2023
Department of Kidney Disease, Kawashima Hospital.
X-linked Alport syndrome is a hereditary progressive renal disease resulting from the disruption of collagen α3α4α5 (IV) heterotrimerization caused by pathogenic variants in the COL4A5 gene. This study aimed to report a male case of X-linked Alport syndrome with a mild phenotype accompanied by an atypical expression pattern of type IV collagen α5 [α5 (IV)] chain in glomerulus. A 38-year-old male presented with proteinuria (2.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!