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SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease.
Sci China Life Sci
January 2025
The Second Affiliated Hospital, The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Zinc homeostasis plays an essential role in maintaining immune function and is tightly regulated by zinc transporters. We previously reported that the zinc transporter SLC39A10, located in the cell membrane, critically regulates the susceptibility of macrophages to inflammatory stimuli; however, the functional role of SLC39A10 in T cells is currently unknown. Here, we identified two SNPs in SLC39A10 that are associated with inflammatory bowel disease (IBD).
View Article and Find Full Text PDFThe Global Burden of Emerging and Re-Emerging Orbiviruses in Livestock: An Emphasis on Bluetongue Virus and Epizootic Hemorrhagic Disease Virus.
Viruses
December 2024
School of Veterinary Medicine, Murdoch University, Perth, WA 6150, Australia.
Bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) are vector-borne orbiviruses that pose an emerging threat to livestock, including cattle and sheep. This review summarizes the global distribution, genetic diversity, and key factors driving their spread along with the existing knowledge gaps and recommendations to mitigate their impact. Both viruses cause hemorrhagic disease in susceptible ruminants and are commonly reported in tropical and subtropical regions including North America, Asia, Africa, Oceania, and some parts of Europe.
View Article and Find Full Text PDFModeling and Simulation of Dynamic Recrystallization Microstructure Evolution for GCr15 Steel Using the Level Set Method.
Materials (Basel)
January 2025
Department of Mechanical Engineering, Jeju National University, 102 Daehak-Ro, Jeju-si 63243, Republic of Korea.
The microstructure of metallic materials plays a crucial role in determining their performance. In order to accurately predict the dynamic recrystallization (DRX) behavior and microstructural evolution during the hot deformation process of GCr15 bearing steel, a microstructural evolution model for the DRX process of GCr15 steel was established by combining the level set (LS) method with the Yoshie-Laasraoui-Jonas dislocation dynamics model. Firstly, hot compression tests were conducted on GCr15 steel using the Gleeble-1500D thermal simulator, and the hardening coefficient and dynamic recovery coefficient of the Yoshie-Laasraoui-Jonas model were derived from the experimental flow stress data.
View Article and Find Full Text PDFCurrent Status, Challenges, and Perspectives in the Conservation of Native Honeybees and Beekeeping in Cambodia.
Insects
January 2025
Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
The four honeybee species native to Cambodia-, , , -play a vital role in ecosystem health and agricultural productivity through their pollination activities. Beekeeping in Cambodia has primarily developed around the introduced species . However, it remains underdeveloped compared to neighboring countries, with wild honey collection continuing to play a significant role.
View Article and Find Full Text PDFEffect of Gene Polymorphisms on Fatty Acid Composition, Chemical Composition, and Carcass Traits in Sonid Sheep.
Animals (Basel)
January 2025
The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, China.
Fatty acids (FAs) are a group of organic compounds that are regulated by polygenic and environmental factors and affect the taste, nutritional value, and quality of meat. Lamb meat is rich in FAs required by the human body, which has directed more attention to sheep research and meat production. The fatty acid-binding protein 4 () gene is considered a candidate gene that can affect FA composition in livestock.
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