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[Arthropathy as the first manifestation of undiagnosed hemochromatosis: a case report on an unusual course].
Dtsch Med Wochenschr
January 2025
RZ Rheumazentrum Rheinland-Pfalz GmbH, Bad Kreuznach, Deutschland.
A 54-year-old man presented with increasing arthralgia and swelling of the metacarpophalangeal (MCP) joints II and III for approximately 2 years. He also reported morning stiffness and joint pain in both knees and feet.Both MCP joints II and III and the proximal interphalangeal joints II and III were tender without visible swelling.
View Article and Find Full Text PDFCurrent State of the Neuroscience of Fear Extinction and Its Relevance to Anxiety Disorders.
Curr Top Behav Neurosci
January 2025
Leibniz Institute for Resilience Research (LIR), Mainz, Germany.
The elucidation of the functional neuroanatomy of human fear, or threat, extinction has started in the 2000s by a series of enthusiastically greeted functional magnetic resonance imaging (fMRI) studies that were able to translate findings from rodent research about an involvement of the ventromedial prefrontal cortex (vmPFC) and the hippocampus in fear extinction into human models. Enthusiasm has been painfully dampened by a meta-analysis of human fMRI studies by Fullana and colleagues in 2018 who showed that activation in these areas is inconsistent, sending shock waves through the extinction research community. The present review guides readers from the field (as well as non-specialist readers desiring safe knowledge about human extinction mechanisms) during a series of exposures with corrective information.
View Article and Find Full Text PDF[The effects of environmental stressors on cardiovascular health].
Inn Med (Heidelb)
December 2024
Zentrum für Kardiologie, Universitätsmedizin Mainz, Johannes Gutenberg-Universität, Langenbeckstraße 1, 55131, Mainz, Deutschland.
Noncommunicable diseases (NCDs) are responsible for the premature deaths of more than 38 million people each year, making them the leading cause of the global burden of disease, accounting for 70% of global mortality. The majority of these deaths are caused by cardiovascular diseases. The risk of NCDs is closely related to exposure to environmental stressors such as air pollution, noise pollution, artificial light at night, and climate change, including extreme heat, sandstorms, and wildfires.
View Article and Find Full Text PDFPRIO - a prospective integrative oncology registry: trial protocol.
Front Oncol
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Research Group Integrative Medicine, Department of General and Visceral Surgery, University Hospital Ulm, Ulm, Germany.
Background: Integrative Oncology (IO) - the use of lifestyle modifications, mind-body practices and natural products in oncology - is increasingly asked for by patients. The evidence base of IO is growing and IO measures are included in national guidelines. Still, many questions about IO remain unanswered or still show a poor evidence base.
View Article and Find Full Text PDFSelective Decarboxylative Fluorination of β-Keto Acids in Aqueous Media: F-NMR-Assisted Batch Optimization and Transfer to Continuous Flow.
Chemistry
December 2024
Fraunhofer Institute for Microengineering and Microsystems IMM, Carl-Zeiss-Strasse 18-20, 55129, Mainz, Germany.
The selective decarboxylative fluorination of 3-oxo-3-phenylpropionic acid is used as a benchmark reaction to optimize it under biocompatible conditions in batch and to transfer it to continuous flow mode. The reaction conditions are varied with respect to temperature, fluorinating reagents, inorganic base additives, and pH, as these parameters have been identified as having a significant impact on the process. The formation of the products and any by-products is analyzed using gas chromatography (GC) and F nuclear magnetic resonance spectroscopy (NMR).
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