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Actin instability alters red blood cell mechanics and Piezo1 channel activity.
Biomech Model Mechanobiol
January 2025
CNR Istituto Officina Dei Materiali, Area Science Park Basovizza, S.S. 14, Km 163,5, 34149, Trieste, Italy.
The organization and dynamics of the spectrin-actin membrane cytoskeleton play a crucial role in determining the mechanical properties of red blood cells (RBC). RBC are subjected to various forces that induce deformation during blood microcirculation. Such forces also regulate membrane tension, leading to Piezo1 channel activation, which is functionally linked to RBC dehydration through calcium influx and subsequent activation of Gardos channels, ultimately resulting in variations in RBC volume.
View Article and Find Full Text PDFActin Polymerization Status Regulates Tenocyte Homeostasis Through Myocardin-Related Transcription Factor-A.
Cytoskeleton (Hoboken)
November 2024
Department of Biomedical Engineering, University of Delaware, Newark, Delaware, USA.
The actin cytoskeleton is a potent regulator of tenocyte homeostasis. However, the mechanisms by which actin regulates tendon homeostasis are not entirely known. This study examined the regulation of tenocyte molecule expression by actin polymerization via the globular (G-) actin-binding transcription factor, myocardin-related transcription factor-a (MRTF).
View Article and Find Full Text PDFEarly and late phases of liver sinusoidal endothelial cell (LSEC) defenestration in mouse model of systemic inflammation.
Cell Mol Biol Lett
November 2024
Institute of Nuclear Physics Polish Academy of Sciences, 31342, Krakow, Poland.
Background: Liver sinusoidal endothelial cells (LSECs) have transcellular pores, called fenestrations, participating in the bidirectional transport between the vascular system and liver parenchyma. Fenestrated LSECs indicate a healthy phenotype of liver while loss of fenestrations (defenestration) in LSECs is associated with liver pathologies.
Methods: We introduce a unique model of systemic inflammation triggered by the deletion of Mcpip1 in myeloid leukocytes (Mcpip1LysM) characterised by progressive alterations in LSEC phenotype.
Neurosteroids Alter p-ERK Levels and Tau Distribution, Restraining the Effects of High Extracellular Calcium.
Int J Mol Sci
October 2024
Division of Animal and Human Physiology, Department of Biology, National and Kapodistrian University of Athens, University Campus, 15784 Athens, Greece.
Neurosteroids are undeniably regarded as neuroprotective mediators, regulating brain function by rapid non-genomic actions involving interference with microtubules. Conversely, hyperphosphorylated Tau is considered responsible for the onset of a plethora of neurodegenerative diseases, as it dissociates from microtubules, leading to their destabilization, thus impairing synaptic vesicle transport and neurotransmission. Consequently, we aimed to investigate the effects of neurosteroids, specifically allopregnanolone (Allo) and dehydroepiandrosterone (DHEA), on the levels of total and phosphorylated at Serine 404 Tau (p-Tau) in C57BL/6 mice brain slices.
View Article and Find Full Text PDFCharacterizing the interplay between Acinetobacter baumannii, A549 cells, and anti-Omp34 antibodies: implications for adherence, internalization, and cytotoxicity.
Folia Microbiol (Praha)
October 2024
Department of Biology, Shahed University, Tehran, Iran.
Acinetobacter baumannii thrives within eukaryotic cells, influencing persistence, treatment approaches, and progression of disease. We probed epithelial cell invasion by A. baumannii and the influence of antibodies raised to outer membrane protein 34 (Omp34) on epithelial interactions.
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