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Immunohistochemical study of fibroblasts and mast cells in chronic submandibular sialadenitis.
Oral Dis
April 2008
Department of Oral Medicine and Oral Pathology, Dental School, University of Thessaloniki, Greece.
Aim: To further our understanding of the processes involved in fibrosis that occurs in chronic submandibular sialadenitis by investigating the distribution of myofibroblasts, CD34-positive fibroblasts and tryptase-containing mast cells.
Materials And Methods: Thirty specimens of chronic submandibular sialadenitis with varying degrees of fibrosis and five normal submandibular glands were examined immunohistochemically for the presence of CD34, alpha-smooth-muscle-actin, desmin and tryptase.
Results: Myofibroblasts were not demonstrated by the techniques for alpha-smooth-muscle-actin or desmin.
Distribution of tryptase-containing mast cells and metallothionein reactive astrocytes in human brains with amyloid deposits.
Inflamm Res
April 2007
Medical Research Centre, Department of Experimental and Clinical Neuropathology, Polish Academy of Sciences, 5 Pawinskiego str, 02-106 Warsaw, Poland.
CGRP-immunoreactive nerves in prurigo nodularis--an exploration of neurogenic inflammation.
J Cutan Pathol
August 2000
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
Background: The present study has explored the localization and distribution of calcitonin gene-related peptide (CGRP)-immunoreactive (IR) nerve fibers in prurigo nodularis, especially emphasizing its relationships to mast cells and eosinophils, which all are important contributors to inflammation.
Methods: The exact localization of CGRP in the nerve fibers of prurigo nodularis lesional skin has been clarified by an ultrastructural immunogold labelling technique; and the relationships of CGRP-IR nerve fibers to tryptase-IR mast cells or eosinophil cationic protein (ECP)-IR eosinophils were also investigated by immunofluorescence double-labelling.
Results: This ultrastructural study has demonstrated that CGRP immunoreactivity is increased in the dense-core vesicles in the axons of the prurigo nodularis lesional skin; the axons which contain CGRP are, in addition, enlarged and have more dense-core vesicles than the axons which do not contain CGRP.
Mast cell density and subtypes in the skin of Shar Pei dogs with cutaneous mucinosis.
Zentralbl Veterinarmed A
July 1999
Institute of Animal Pathology, University of Bern, Switzerland.
Skin biopsies from 13 Shar Peis showing signs of cutaneous mucinosis and 13 control dogs of different breeds with no clinical or histological evidence of skin disease were examined. One section of each tissue sample was stained with haematoxylin and eosin, and another with toluidine blue to demonstrate the sulphated acid glycosaminoglycans in mast cell (MC) granules. To investigate the MC subtypes involved, the tryptase and chymase content of mast cells was evaluated by a double enzyme-immunohistochemical staining technique.
View Article and Find Full Text PDFProteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase.
Exp Dermatol
August 1999
Department of Surgery, University of California, San Francisco, USA.
Proteinase-activated receptor-2 (PAR-2) is a G-protein coupled receptor. Tryptic proteases cleave PAR-2 exposing a tethered ligand (SLIGKV), which binds and activates the receptor. Although PAR-2 is highly expressed by cultured keratinocytes and is an inflammatory mediator, its precise localization in the normal and inflamed human skin is unknown, and the proteases that activate PAR-2 in the skin have not been identified.
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