AI Article Synopsis
- Two series of KSP inhibitors were analyzed, leading to the development of dihydropyrazolobenzoxazines with promising properties for cancer treatment.
- The study details the synthesis and characterization of these inhibitors, along with important pharmacokinetic and in vivo findings.
- A significant step in the synthesis process involved a [3+2] cycloaddition to create the core structure, followed by a specific method to add a quaternary center.
Article Abstract
Observations from two structurally related series of KSP inhibitors led to the proposal and discovery of dihydropyrazolobenzoxazines that possess ideal properties for cancer drug development. The synthesis and characterization of this class of inhibitors along with relevant pharmacokinetic and in vivo data are presented. The synthesis is highlighted by a key [3+2] cycloaddition to form the pyrazolobenzoxazine core followed by diastereospecific installation of a quaternary center.
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| http://dx.doi.org/10.1016/j.bmcl.2007.07.067 | DOI Listing |
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