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Fiber Sorbents - A Versatile Platform for Sorption-Based Gas Separations.
Acc Mater Res
January 2025
School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30322, United States.
Increasing demand for high-purity fine chemicals and a drive for process intensification of large-scale separations have driven significant work on the development of highly engineered porous materials with promise for sorption-based separations. While sorptive separations in porous materials offer energy-efficient alternatives to longstanding thermal-based methods, the particulate nature of many of these sorbents has sometimes limited their large-scale deployment in high-throughput applications such as gas separations, for which the necessary high feed flow rates and gas velocities accrue prohibitive operational costs. These processability limitations have been historically addressed through powder shaping methods aimed at the fabrication of structured sorbent contactors based on pellets, beads or monoliths, commonly obtained as extrudates.
View Article and Find Full Text PDFMolecular mechanism of long chain non coding RNA LINC00511 influencing breast cancer stem cells: Mechanism of VEGFR1 protein.
Int J Biol Macromol
January 2025
Department of Hepatobiliary Surgery, The First Affiliated Hospital, Jinan University, Guangzhou 510630, Guangdong, PR China; Department of Breast and Thyroid Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, PR China; Key Laloratory of Molecular Pathology in Tumors of Guangxi, Baise 533000, Guangxi, PR China; Department of Oncology-Pathology, Karolinska Institutet, Stockholm SE-17176, Sweden. Electronic address:
A comprehensive investigation into the mechanism of VEGFR1 protein in this process was undertaken. Lentivirus-mediated RNA interference was employed to inhibit the expression of LINC00511 in breast cancer cell lines, and changes in breast cancer stem cell markers, including CD44+/CD24-, were monitored using flow cytometry. Additionally, the interaction between VEGFR1 protein and LINC00511 and the activation of its downstream signaling pathway were investigated through co-immunoprecipitation (Co-IP) and Western blot techniques.
View Article and Find Full Text PDFThe impact of glidant addition on the loss-in-weight feeding of active pharmaceutical ingredients.
Int J Pharm
January 2025
Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium. Electronic address:
In recent years, continuous manufacturing (CM) has become increasingly popular in the pharmaceutical industry for the production of oral solid dosage (OSD) forms. Most of the newly developed active pharmaceutical ingredients (APIs) nowadays are extremely cohesive and sticky with a mean particle size particle of <100μm, a wide particle size distribution (PSD) and a high tendency to agglomerate, making them difficult to accurately dose using loss-in-weight equipment during CM. In this research paper, the effect of various glidants on the volumetric and gravimetric feeding of several APIs was assessed.
View Article and Find Full Text PDFEngineering electrogenetic interfaces for mammalian cell control.
Cell Chem Biol
January 2025
Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; Faculty of Science, University of Basel, Mattenstrasse 26, 4058 Basel, Switzerland. Electronic address:
Human body cells and our daily electronic devices both communicate information within their distinct worlds by regulating the flow of electrons across specified membranes. While electronic devices depend on the flow of electrons generated by conductive materials to communicate within a digital network, biological systems use ion gradients, created in analog biochemical reactions, to trigger biological data transmission throughout multicellular systems. Electrogenetics is an emerging concept in synthetic biology in which electrons generated by digital electronic devices program customized electron-responsive biological units within living cells.
View Article and Find Full Text PDFNutrient circularity from waste to fertilizer: A perspective from LCA studies.
Sci Total Environ
January 2025
Material Flow Management and Resource Economy, Institute IWAR, Technical University of Darmstadt, Franziska-Braun-Straße 7, 64287 Darmstadt, Germany.
Nutrient circularity, an exemplification of circular economy (CE), is situated in the waste/wastewater-agriculture nexus. Recycling nutrient elements from waste streams to fertilizer products amplify the sustainable management of resources and intersect technical and biological loops, a concept developed for CE. Such a complex system needs to be directed by robust assessment methods such as life cycle assessment (LCA) to identify trade-offs and potentials.
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