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Follicular growth, ovulation, and pregnancy responses to PGF-indued luteolysis and spontaneous return to estrus in Standardbred mares with large diestrous follicles.

J Equine Vet Sci

January 2025

Equine Fertility Group, Faculty of Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Valencia, Spain; Broline International AB, 51293 Svenljunga, Sweden. Electronic address:

The objective of this study was to compare the fertility of diestrous mares with a follicle ≥ 30 mm in diameter treated with prostaglandin F2α (PGF) (PGF group) or left untreated for 7 days (SP group). Standardbred mares (n = 46) were assigned randomly to the SP (n = 23) and PGF groups (n = 23) when they were identified with a corpus luteum (CL) of unknown age and a follicle ≥ 30 mm in diameter (Day 0). The most frequent outcome in the PGF group was estrus and ovulation of the dominant follicle (74 %), while the outcomes of the SP mares 7 days after Day 0 were more variable: estrus and follicle regression (30 %), diestrous ovulation (22 %) and diestrus along with follicle regression (26 %) of the dominant follicles.

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The study evaluated strategies for induction of ovulation at the end of timed AI (TAI) protocols initiated after a novel presynchronization strategy. A total of 909 lactating dairy cows from 6 dairy herds initiated a presynchronization protocol on d -15 with an intravaginal progesterone (P4) implant and 7 d later (d -8) were treated with 1.0 mg of estradiol cypionate (EC) and 0.

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The main objectives of the present study were to determine the effects of presynchronizing with a 1.0 g intravaginal progesterone device (IVPD) and prostaglandin F2α and to assess the effects of re-utilization of IVPD in a 2x2 factorial design, on the ovulatory response to first GnRH, ovarian status at different protocol stages, estrus expression and fertility in beef heifers submitted to a 5d-CO-Synch + Progesterone (P4) protocol. Beef heifers (n = 564) were assigned to 1 of 2 treatments at D-15: Pres5 (n = 283), where heifers received a (IVPD) for 5 days and administration of prostaglandin F2α (25 mg of dinoprost) at D-10; and Control (n = 281), where heifers received no treatment.

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Article Synopsis
  • Cystic ovarian disease (COD) is a reproductive issue that affects Egyptian buffaloes postpartum, leading to significant economic challenges.
  • The study focused on the effectiveness of the GnRH/PGF2α treatment protocol for improving fertility and reducing economic losses linked to COD.
  • Results showed that treated buffaloes had improved hormonal profiles, decreased inflammatory markers, and notable structural changes in their reproductive tissues compared to untreated buffaloes.
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Effects of thiacloprid, a neonicotinoid pesticide, on rat reproductive system: Pregnancy hormone disruption and abortion trends.

Pestic Biochem Physiol

November 2024

Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

Thiacloprid (TCL), commonly known as Biscaya, is among the most widely used pesticides in agriculture, designed to eliminate insects by targeting their nicotinic receptors. This study explores the effects of orally administering TCL (at a dose of 50 mg/kg) on the hormone secretion crucial for pregnancy and the factors influencing abortion throughout the early, middle, and late stages of pregnancy in female rats. Following TCL exposure, there were significant increases in levels of 17β-Estradiol, prostaglandins F and E, and serum oxytocin hormone in different stages of pregnancy.

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