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Biomechanics of flail chest injuries: tidal volume and respiratory work changes in multiple segmental rib fractures.
Eur J Trauma Emerg Surg
January 2025
Julius Wolff Institute, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Background: Flail chest (FC) injuries are segmental osseous injuries of the thorax that typically result from high-energy blunt trauma and regularly occur in multiple trauma (MT) patients. FC injuries are associated with paradoxical chest wall movements and, thus, have a high risk of respiratory insufficiency or even death. An increasing number of studies recommend an early surgical stabilization of FC injuries, but a definite trigger that would indicate surgery has, thus far, not been identified.
View Article and Find Full Text PDFA quality assurance protocol for reliable and reproducible multi-TI arterial spin labeling perfusion imaging in rat livers.
MAGMA
January 2025
Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.
Objective: To establish an arterial spin labeling (ASL) protocol for rat livers that improves data reliability and reproducibility for perfusion quantification.
Methods: This study used respiratory-gated, single-slice, FAIR-based ASL imaging with multiple inversion times (TI) in rat livers. Quality assurance measures included: (1) introduction of mechanical ventilation to ensure consistent respiratory cycles by controlling the respiratory rate (45 bpm), tidal volume (10 ml/kg), and inspiration: expiration ratio (I:E ratio, 1:2), (2) optimization of the trigger window for consistent trigger points, and (3) use of fit residual map and coefficient of variance as metrics to assess data quality.
Ferritinophagy mediated by the AMPK/ULK1 pathway is involved in ferroptosis subsequent to ventilator-induced lung injury.
Respir Res
December 2024
Department of Anesthesiology, Guangxi Medical University Cancer Hospital, He Di Rd No.71, Nanning, 530021, P. R. China.
Mechanical ventilation (MV) remains a cornerstone of critical care; however, its prolonged application can exacerbate lung injury, leading to ventilator-induced lung injury (VILI). Although previous studies have implicated ferroptosis in the pathogenesis of VILI, the underlying mechanisms remain unclear. This study investigated the roles of ferritinophagy in ferroptosis subsequent to VILI.
View Article and Find Full Text PDFThe Management of Interstitial Lung Disease in the ICU: A Comprehensive Review.
J Clin Med
November 2024
Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Article Synopsis
- Interstitial lung disease (ILD) includes a variety of lung diseases marked by inflammation and fibrosis, often leading patients to require hospitalization and possibly ICU care due to respiratory failure.
- Diagnosis of ILD relies heavily on chest CT scans, while acute exacerbations necessitate thorough evaluation for triggers and possible infections, with treatments like corticosteroids, oxygen therapy, and careful ventilation strategies.
- Advanced treatments like lung transplantation may be considered for those with end-stage ILD, but the decision hinges on the patient's condition and urgency of the situation.
Near real-time monitoring of the Biscayne Bay Watershed (South Florida, USA) and major tributaries by water quality research buoys.
Sci Total Environ
December 2024
Institute of Environment, Florida International University, 11200 SW 8th Street, Modesto A. Maidique Campus, Miami, FL 33199, USA; Department of Chemistry and Biochemistry, Florida International University, 300 NE 151(st) Street, Marine Science Building 230/232, Biscayne Bay Campus, North Miami, FL 33181, USA; Environmental Analysis Research Laboratory, Florida International University, 300 NE 151(st) Street, Marine Science Building 232, Biscayne Bay Campus, North Miami, FL 33181, USA. Electronic address:
Biscayne Bay (South Florida) is a subtropical estuary that requires freshwater inputs to maintain its ecological balance. Over the past 50+ years, the bay has been disrupted by contaminated freshwater released from tributaries and canals, negatively affecting its water quality. Specific areas of the bay have been recognized as impaired with respect to nutrients, chlorophyll and bacterial contamination.
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