The emergence of applied mathematics as a discipline in the United States is traditionally associated with World War II. Hungarian-born Theodore von Kármán was among those who had waged a long and vigorous campaign well before the war to make applied mathematics respectable to engineers and mathematicians. While advocating the use of mathematics and physics to solve applied problems, he challenged the prevailing philosophy of engineering programs, locked horns with recalcitrant journal editors, and generally encountered the obstacles to building a discipline that cuts across conventional boundaries.
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http://dx.doi.org/10.1126/science.222.4630.1300 | DOI Listing |
Mod Pathol
January 2025
Interdisciplinary Oncology, University of British Columbia, Vancouver, BC, Canada; MAPcore, University of British Columbia, Vancouver, BC, Canada. Electronic address:
Assessment of the tumor immune microenvironment can be used as a prognostic tool for improved survival and as a predictive biomarker for treatment benefit, particularly from immune modulating treatments including cytotoxic chemotherapy. Using Digital Spatial Profiling (DSP), we studied the tumor immune microenvironment of 522 breast cancer cases by quantifying 35 immune biomarkers on tissue microarrays from the MA.5 phase III clinical trial.
View Article and Find Full Text PDFAdv Colloid Interface Sci
January 2025
Breakthrough Technologies, Deakin, ACT, Australia.
The glycocalyx and its associated endothelial surface layer which lines all cell membranes and most tissues, dwarfs the phospholipid membrane of cells in extent. Its major components are sulphated polymers like heparan and chondroitin sulphates and hyaluronic acid. These form a fuzzy layer of unknown structure and function.
View Article and Find Full Text PDFUpdates Surg
January 2025
Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Clinical risk prediction models are ubiquitous in many surgical domains. The traditional approach to develop these models involves the use of regression analysis. Machine learning algorithms are gaining in popularity as an alternative approach for prediction and classification problems.
View Article and Find Full Text PDFJ Mol Model
January 2025
PG & Research Department of Mathematics, Sanatana Dharma College, Kerala University, Alappuzha, Kerala, 688003, India.
Holey nanographene, an allotrope of carbon arranged in two dimensions, has gained remarkable attention as a nanomaterial with several potential uses in numerous industries, such as electronics, energy storage, healthcare, and environmental cleanup, because of its high carrier mobility, flexibility, transparency, high surface area, conductivity, and chemical stability. The fundamental holey nanographene is assembled in a linear form to create the holey nanographene chain (HNC) that is being discussed. To fully utilize it in various applications, it is essential to comprehend the basic ideas guiding its behavior at the nanoscale; for that, we find various topological indices for this holey nanographene chain using the cut method.
View Article and Find Full Text PDFEur Child Adolesc Psychiatry
January 2025
Department of Neurology, Haukeland University Hospital, Jonas Lies vei 71, 5053, Bergen, Norway.
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