Creation of hemocompatible materials resistant to calcinosis for plastic cardiosurgery call for employment of combined methods of their evaluation in experiment. The present study deals with some biochemical and physico-chemical aspects of biomaterial calcification inhibition on reduction of their porosity by means of N-vinylpyrrolidone, and also on immobilization of diphosphonates, phosphonates, and anti-aggregants. The method of radiation copolymerization was employed for immobilization of active agents. The effects of different biotissue specimens of varying modifications (pig aortal valves and cattle pericardium) and of Lavsan (polyethyleneterephthalate) on coagulation factor activation were studied in vivo (in goat) and in vitro. The specimen surface was inspected prior to and after the contact with blood and plasma using the techniques of scanning electron microscopy and photoelectron spectroscopy. The influence of the modifications on the calcium and phosphorus accumulation were studied after subcutaneous implantation of the specimens to rats, and the aggregating capacity of blood platelets was determined in incubation of Lavsan treated with an anti-aggregant. Combined studies revealed the optimal modification routine and the most active agents enabling one to obtain biomaterials that not only are resistant to calcification but also possess good hemocompatibility.
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