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Experimenting with care and cod: On document-practices, versions of care and fish as the new experimental animal.
Soc Stud Sci
October 2024
University of Oslo, Oslo, Norway.
A key ambition in care studies has been to study care in practice and practice. By turning towards practices, care studies has rendered visible and acknowledged important work that is not captured through looking at formal procedures or official and written materials, such as policy documents and medical protocols. In this literature, document materials and the written have often been seen as unable to demonstrate and address the 'specificities of care' (Mol et al.
View Article and Find Full Text PDFChaperone function in antigen presentation by MHC class I molecules-tapasin in the PLC and TAPBPR beyond.
Front Immunol
July 2023
Molecular Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Peptide loading of MHC-I molecules plays a critical role in the T cell response to infections and tumors as well as to interactions with inhibitory receptors on natural killer (NK) cells. To facilitate and optimize peptide acquisition, vertebrates have evolved specialized chaperones to stabilize MHC-I molecules during their biosynthesis and to catalyze peptide exchange favoring high affinity or optimal peptides to permit transport to the cell surface where stable peptide/MHC-I (pMHC-I) complexes are displayed and are available for interaction with T cell receptors and any of a host of inhibitory and activating receptors. Although components of the endoplasmic reticulum (ER) resident peptide loading complex (PLC) were identified some 30 years ago, the detailed biophysical parameters that govern peptide selection, binding, and surface display have recently been understood better with advances in structural methods including X-ray crystallography, cryogenic electron microscopy (cryo-EM), and computational modeling.
View Article and Find Full Text PDF'The Machine Takes Our Jobs Away': The problem of technological unemployment in the work of Chicago sociologist William F. Ogburn.
J Hist Behav Sci
October 2023
Institute for the History and Philosophy of Science and Technology, University of Toronto, Toronto, Ontario, Canada.
This paper examines the Chicago sociologist William F. Ogburn's (1886-1959) views about technological unemployment, which were intimately connected to his analysis of the social impacts of technological developments and resulting social problems due to cultural lag. We trace the development of his views as seen through his well-known 1922 book, Social Change with Respect to Culture and Original Nature, his important contributions to the President's Research Committee on Social Trends (1933), and his lesser-known pamphlets designed for a broader audience-Living with Machines (1933), You and Machines (1934), and Machines and Tomorrow's World (1938).
View Article and Find Full Text PDFSurgical practice and Ayurveda: A realistic analysis of the current debate.
J Ayurveda Integr Med
January 2021
Department of Shalakya Tantra, Faculty of Ayurveda, Banaras Hindu University, Varanasi, India.
The recent notification issued by the Central Council of Indian Medicine making it compulsory for the postgraduate students of two streams of Ayurveda (Shalya Tantra and Shalakya Tantra) to be trained in different kinds of modern surgical procedures as a part of their curricula has led to a nation-wide debate. While practitioners from biomedical sciences are voicing their concerns against the decision, Ayurveda professionals are seen defending the same. In this article we try to look at this issue from a dispassionate and realistic point of view.
View Article and Find Full Text PDFThe lived experiences of elderly dementia patients in Taiwan.
Int J Ment Health Nurs
June 2019
School of Nursing & Dean of Academic Affairs, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
The lived experiences of elderly dementia patients are affected by their cultural beliefs. This study aims to explore the lived experiences of elderly dementia patients in Taiwan in order to understand how they view their lives given the cognitive impairments that they suffer from. A descriptive phenomenological approach was undertaken in 12 elderly dementia patients who were selected using purposive sampling.
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