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Impact of Climatic Factors on the Temporal Trend of Malaria in India from 1961 to 2021.
Trop Med Infect Dis
December 2024
ICMR-Vector Control Research Centre Field Station, No. 4, Sarojini Street, Chinna Chokkikulam, Madurai 625 002, Tamil Nadu, India.
Malaria remains a significant public health problem in India. Although temperature influences Anopheline mosquito feeding intervals, population density, and longevity, the reproductive potential of the Plasmodium parasite and rainfall influence the availability of larval habitats, and evidence to correlate the impact of climatic factors on the incidence of malaria is sparse. Understanding the influence of climatic factors on malaria transmission will help us predict the future spread and intensification of the disease.
View Article and Find Full Text PDFEvolution of HIV Epidemic and Emerging Challenges - China, 1989-2023.
China CDC Wkly
November 2024
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Introduction: This study aimed to provide a comprehensive analysis of the human immunodeficiency virus (HIV) epidemiological landscape in China through a historical review and current assessment.
Methods: Data were extracted from China's HIV/AIDS Comprehensive Response Information Management System (CRIMS). Transmission patterns across different phases were visualized using stacked area charts.
Scatter correction for contrast-enhanced digital breast tomosynthesis with a dual-layer detector.
J Med Imaging (Bellingham)
January 2025
Stony Brook Medicine, Department of Radiology, Stony Brook, New York, United States.
Purpose: Contrast-enhanced digital breast tomosynthesis (CEDBT) highlights breast tumors with neo-angiogenesis. A recently proposed CEDBT system with a dual-layer (DL) flat-panel detector enables simultaneous acquisition of high-energy (HE) and low-energy (LE) projection images with a single exposure, which reduces acquisition time and eliminates motion artifacts. However, x-ray scatter degrades image quality and lesion detectability.
View Article and Find Full Text PDFIntegrating weather indices with field performance of novel fungicides for management of late blight of potato (Phytophthora infestans) in North Eastern Himalayan Region of India.
PLoS One
December 2024
ICAR - Agricultural Technology Application Research Institute, Zone VII, Umiam, Meghalaya, India.
Article Synopsis
- Phytophthora infestans is a serious pathogen causing late blight disease in potatoes, impacting them throughout their growth stages and spreading quickly.
- Field experiments in the 2020-21 and 2021-22 winter seasons tested the effectiveness of novel fungicides, showing that certain treatments resulted in the lowest disease incidence and highest tuber yields.
- The study found that late blight is positively correlated with temperature, humidity, and sunlight, and the use of specific fungicides significantly reduced disease severity and increased profitability compared to untreated controls.
The Effect of Metformin and Hydrochlorothiazide on Cytochrome P450 3A4 Metabolism of Ivermectin: Insights from In Silico Experimentation.
Int J Mol Sci
November 2024
Department of Biochemistry and Microbiology, University of Zululand, Kwa-Dlangezwa 3886, South Africa.
The spread of SARS-CoV-2 has led to an interest in using ivermectin (a potent antiparasitic agent) as an antiviral agent despite the lack of convincing in vivo clinical data for its use against COVID-19. The off-target prophylactic use of ivermectin adds a substantial risk of drug-drug interactions with pharmaceutical medications used to treat chronic conditions like diabetes and hypertension (metformin and hydrochlorothiazide, respectively). Therefore, this study aims to evaluate the potential drug-drug interactions between ivermectin with either metformin or hydrochlorothiazide.
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