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Engineered T cells secreting αB7-H3-αCD3 bispecific engagers for enhanced anti-tumor activity against B7-H3 positive multiple myeloma: a novel therapeutic approach.
J Transl Med
January 2025
Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Background: Multiple myeloma (MM) is an incurable plasma cell malignancy with increasing global incidence. Chimeric antigen receptor (CAR) T-cell therapy targeting BCMA has shown efficacy in relapsed or refractory MM, but it faces resistance due to antigen loss and the tumor microenvironment. Bispecific T-cell engaging (BITE) antibodies also encounter clinical challenges, including short half-lives requiring continuous infusion and potential toxicities.
View Article and Find Full Text PDF[Establishment and application of chloroplast genome database with the largest number of species in world].
Zhongguo Zhong Yao Za Zhi
December 2024
Experimental Research Center, China Academy of Chinese Medical Sciences Beijing 100700, China.
The chloroplast genome is an important tool for studying plant classification, evolution, and the heterologous production of secondary metabolites and protein drugs. With advancements in sequencing technology and reductions in sequencing costs, chloroplast genome data have rapidly accumulated. However, existing chloroplast genome databases suffer from issues such as incomplete data, inadequate management, and inconsistent, inaccurate information, posing significant challenges for the development and utilization of the chloroplast genome.
View Article and Find Full Text PDFRadiation exposure during cardiac interventions in CHD: German Registry 2012-2020.
Thorac Cardiovasc Surg
January 2025
Pediatric Cardiology, University Hospital Tuebingen, Tubingen, Germany.
Background: Since patients with congenital heart defects (CHD) frequently require life-long medical care and repeat invasive treatment, radiation exposure during interventional procedures is a relevant issue concerning potential radiation related risks. Therefore, an analysis on radiation data from the German Registry for Cardiac Operations and Interventions in patients with CHD was performed.
Methods: From January 2012 until December 2020 a total of 28,374 cardiac catheter interventions were recorded.
Transforming medical anthropology: Community, praxis, and the Black Feminist Health Science Studies Collaboratory.
Med Anthropol Q
January 2025
Department of African American Studies, University of California, Los Angeles, California, USA.
Despite the transformative contributions of Black feminist thought, medical anthropology often fails to recognize or center the works of Black feminist thinkers. We argue that Black feminist theory is critical for a study and praxis of new approaches to healing, health, medicine, illness, disability, and care. We can't continue to simply recognize that current systems are failing us; Black feminist theory moves us past recognition toward transformative liberation.
View Article and Find Full Text PDFOne size does not fit all: the multifaceted impact of COVID-19 on graduate-level behavioral health professions students.
J Am Coll Health
January 2025
Department of Psychology, University of South Florida, Tampa, USA.
Better understanding how behavioral health professions students were impacted by COVID-19 can help educators inform their education practices. The present study examined the impact of COVID-19 among = 83 students enrolled in two universities across five graduate-level behavioral health training programs - clinical mental health counseling, marriage and family therapy, psychiatric nursing, and social work. Participants completed the Epidemic-Pandemic Impacts Inventory (EPII), and descriptive statistics were examined.
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