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Dynamic analysis and optimal control of a hybrid fractional monkeypox disease model in terms of external factors.
Sci Rep
January 2025
Department of Mathematics and Statistics, College of Science, Taif University, P.O. Box 11099, 21944, Taif, Saudi Arabia.
The monkeypox virus (MPXV), which is a member of the Orthopoxvirus genus in the class Poxviridae, is the causative agent of the zoonotic viral infection MPXV. The disease is similar to smallpox, but it is usually less dangerous. This study examines the evolution of the MPXV epidemic in Canada with an emphasis on the effects of control employing actual data.
View Article and Find Full Text PDFBiomimetic Nanoplatelets to Target Delivery Hirudin for Site-Specific Photothermal/Photodynamic Thrombolysis and Preventing Venous Thrombus Formation.
Small
December 2022
State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
Due to the high recurrence rate and mortality of venous thrombosis, there is an urgent need for research on antithrombotic strategies. Because of the short half-life, poor targeting capabilities, bleeding complications, and neurotoxic effects of conventional pharmacological thrombolysis methods, it is essential to develop an alternative strategy to noninvasive thrombolysis and decrease the recurrence rate of venous thrombosis. A platelet-mimetic porphyrin-based covalent organic framework-engineered melanin nanoplatform, to target delivery of hirudin to the vein thrombus site for noninvasive thrombolysis and effective anticoagulation, is first proposed.
View Article and Find Full Text PDFSARS-CoV-2 Omicron Variants Reduce Antibody Neutralization and Acquire Usage of Mouse ACE2.
Front Immunol
July 2022
Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
Striking number of mutations found in the spike protein of recently emerged SARS-CoV-2 Omicron subvariants BA.1, BA.2, BA.
View Article and Find Full Text PDFDerivation of "Egyptian varices prediction (EVP) index": A novel noninvasive index for diagnosing esophageal varices in HCV Patients.
J Adv Res
January 2022
Systems and Information Department, Engineering Research Division, National Research Centre, Giza, Egypt.
Introduction: Esophageal Varices (EVs) is one of the major dangerous complications of liver fibrosis. Upper Gastrointestinal (UGI) Endoscopy is necessary for its diagnosis. Repeated examinations for EVs screening severely burden endoscopic units in terms of cost and other side implications; moreover, the lack of public health resources in rural areas and primary hospitals should be considered, particularly in developing countries.
View Article and Find Full Text PDFComparison of Carbapenem-Resistant Microbial Pathogens in Combat and Non-combat Wounds of Military and Civilian Patients Seen at a Tertiary Military Hospital, Philippines (2013-2017).
Mil Med
February 2020
Bacterial Disease Branch, Walter Reed Army Institute of Research, MD 20910-7500.
Article Synopsis
- Bacterial wound infections pose significant risks for both military and civilian populations, influencing guidance for antibiotic treatment during combat injuries.
- The study examined 634 bacterial wound isolates from a Philippine military hospital, identifying a predominance of Staphylococcus aureus and several Gram-negative species, with a notable 8% showing carbapenemase production.
- Molecular testing revealed 94% of the carbapenemase-producing isolates carried blaNDM or blaVIM resistance genes, indicating a potential for horizontal gene transfer among these bacteria, particularly between military and civilian cases.*
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