[Clinical and pathologic features of melanocytic lesion of the central nervous system].

Zhong Nan Da Xue Xue Bao Yi Xue Ban

Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

Published: August 2007

Objective: To investigate the clinical and pathologic features of melanocytic lesion of the central nervous system.

Methods: We analyzed the clinical features, neuroimages, and operational and neuropathological findings of 2 patients of neurocutaneous melanosis and 4 patients of primary leptomeningeal melanoma.

Results: All the 6 patients had the common clinical features of intracranial hypertension and epilepsy. Brain CT and MRI showed abnormal signals. More melanin pigment nevi were found on the skin of the 2 patients subjected to neurocutaneous melanosis. The other 4 patients subjected to primary leptomeningeal melanoma had no melanin pigment nevus on the skin, but the brain section displayed positive meningeal melanoma.

Conclusion: Intracranial hypertension and epilepsy are the main clinical manifestations of melanocytic lesion of the central nervous system, and cutaneous lesion and radiological findings are very important for the diagnosis.

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