AI Article Synopsis
- This study aimed to explore how glossy ganoderma decoction can help in cases of Amanita mushroom poisoning.
- Researchers conducted experiments on 20 male rabbits, dividing them into control and treatment groups to assess liver function and RNA polymerase activity.
- Results showed that glossy ganoderma decoction improved liver function and RNA polymerase activity in the treatment groups, suggesting it has protective effects against mushroom toxicity.
Article Abstract
Objective: To investigate the mechanism of glossy ganoderma decoction in Amanita mushroom poisoning.
Methods: Twenty male New Zealand white rabbits were randomly divided into 4 groups, including a normal control, a model poison group, and 2 treatment groups (different doses of glossy ganoderma decoction). The activities of hepatocyte RNA polymerase were measured by ultraviolet spectrophotometry and liver function were measured.
Results: The activities of hepatocyte RNA polymerase of the model group significantly decreased, and those of the 2 treatment groups were significantly higher than those of the model group. There was a dose-dependent manner between the 2 treatment groups ( all Ps<0.01), and the differences of liver function test including total bilirubin (TBIL), direct bilirubin (DB), total bile acid (TBA), and alanine aminotransferase (ALT) in the 4 groups were significant (P<0.01).
Conclusion: Glossy ganoderma decoction may protect the liver from Amanita mushroom poisoning. Its mechanism may be related to the increase of the activities of hepatocyte RNA polymerase.
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