Laser Doppler fluxmetry (LDF) was used to measure skin blood flux and its vasomotion, i.e. rhythmical variations in nineteen patients with post-thrombotic venous insufficiency, and in eight healthy control subjects before and after a single intermittent pneumatic compression treatment session. Following the compression treatment session skin blood flux increased and vasomotion was seen in all the patients. The transcutaneous oxygen tension also increased slightly, but significantly, from 25.4 (range 3-56) mmHg to 30.8 (range 7-61) mmHg (p less than 0.01). It is suggested that IPC treatment decreases venous distention and venous pressure thereby decreasing vasocontrictor stimulus. This seems to restore normal skin blood flow including vasomotion.
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Front Med (Lausanne)
January 2025
Department of Pathology, Montefiore Medical Center, Bronx, NY, United States.
Background: Glecaprevir/pibrentasvir is an effective antiviral therapy for hepatitis C virus infection and is generally regarded safe in patients with renal impairment. However, renal complications are a notable, albeit rare, concern.
Case Presentation: We report a case of acute kidney injury in a man in his 50s with chronic hepatitis C virus, chronic obstructive pulmonary disease, morbid obesity, a history of heroin dependence, and untreated type 2 diabetes mellitus.
J Anus Rectum Colon
January 2025
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Objectives: To describe detailed surgical techniques for totally stapled intracorporeal anastomosis (TSIA) and determine their feasibility and safety by comparing short-term outcomes with those of conventional totally stapled extracorporeal anastomosis (TSEA).
Methods: In total, 59 consecutive patients who underwent laparoscopic colectomy between June 2018 and August 2021 were retrospectively assessed. Linear staplers were used for all anastomoses.
Biochem Biophys Rep
March 2025
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Vitiligo is a common skin depigmentation condition caused by selective destruction of melanocytes. It is regarded as a polygenic disorder. In addition to protein-coding loci, non-coding regions of the genome contribute to the pathogenesis of vitiligo.
View Article and Find Full Text PDFCureus
December 2024
Department of Anesthesiology and Critical Care, Duke University Medical Center, Durham, USA.
Histiocytic disorders include a range of uncommon illnesses marked by the buildup of cells that have developed into macrophages, dendritic cells, or monocytes in diverse tissues and organs. Over 100 distinct subtypes have been documented, exhibiting a diverse array of clinical symptoms, presentations, and histologic features that can be confused with other clinical conditions leading to delayed diagnosis. They affect both children and adults, generating a variety of clinical symptoms that can be limited to one position, numerous areas within one system, or affect many systems in the body.
View Article and Find Full Text PDFSovrem Tekhnologii Med
January 2025
MD, DSc, Professor, Head of the Laboratory of Optical Coherence Tomography Research Institute of Experimental Oncology and Biomedical Technologies; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
Unlabelled: is to demonstrate the effect of fractional CO laser treatment on vulvar skin in lichen sclerosus using multimodal optical coherence tomography (MM OCT).
Materials And Methods: The study included 3 clinical cases of vulvar lichen sclerosus (VLS) (histologically classified as early, early with dermal edema, late) and 2 control cases without vulvar pathology. Patients with VLS underwent 3 procedures of fractional CO laser treatment with an interval of 30-40 days.
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