Adequate portal inflow is essential to the regeneration of a partial liver graft after adult living donor liver transplantation (LDLT). A recipient having large spontaneous portosystemic collaterals with or without portal vein (PV) stenosis would require surgical interruption of large collaterals and/or correction of PV stenosis to prevent postoperative "portal flow steal phenomenon." Intraoperative Doppler ultrasound (IOUS) has been used to estimate the adequacy of portal inflow, but it has a limitation to identify the correct anatomical and hemodynamic parameters of portosystemic collaterals. We initiated to utilize intraoperative cine-portogram (IOCP) to overcome the limitations of IOUS. The spontaneous portosystemic large collaterals in 5 of 156 adult LDLTs from March 2003 to February 2004 were precisely identified not by IOUS but by IOCP, and successfully interrupted. In addition, 3 of these patients had stenotic PV (<1 cm in diameter), which was interfering with the hepatopetal portal flow and the PVs were effectively widened by the placement of intraoperative PV stenting. In conclusion, IOCP seems to be an effective tool for precise detection of the persistent large portosystemic collaterals that were not detected by IOUS, and for monitoring their complete interruption.
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http://dx.doi.org/10.1002/lt.21252 | DOI Listing |
Clin J Gastroenterol
December 2024
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
We report the case of a 70-year-old woman with advanced hepatic encephalopathy (HE) secondary to metabolic dysfunction-associated steatohepatitis (MASH)-related cirrhosis who exhibited an excellent response to portosystemic shunt embolization. Four years earlier, she was diagnosed as having MASH-related cirrhosis accompanied by multiple mesenteric vein-inferior vena cava shunts. As her condition progressed, she suffered recurrent HE that was unresponsive to oral medication, prompting the decision to proceed with shunt embolization.
View Article and Find Full Text PDFFront Pediatr
November 2024
Department of General Surgery, Capital Institute of Pediatrics, Beijing, China.
Objective: To evaluate treatment strategies for congenital intrahepatic portosystemic shunt (CIPSS) based on the experience of treating 27 children.
Methods: Between August 2017 and January 2024, our team treated 27 children with CIPSS. Twelve patients underwent surgical ligation of the portosystemic shunt, while 15 patients diagnosed prenatally received conservative treatment without surgery.
Liver Int
November 2024
Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Background And Aims: Portal hypertension is the main pathophysiological driver of decompensation in patients with liver cirrhosis. Epithelial cell death markers, m30 and m65, correlate with hepatic injury and predict outcomes across various stages of liver disease. We aim (i) to evaluate whether portal hypertension itself contributes to liver outcome-relevant epithelial injury, and (ii) to analyse the capacity of m30/m65 to predict outcome in patients receiving a transjugular intrahepatic portosystemic shunt (TIPS) for refractory ascites.
View Article and Find Full Text PDFEur J Surg Oncol
October 2024
HPB, Minimally Invasive, Robotic and Transplant Surgery Unit, Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy.
Background: Post-hepatectomy liver failure (PHLF) can significantly compromise outcomes, especially in cirrhotic patients. The identification of accurate and non-invasive pre-operative predictors is of paramount importance to appropriately stratify patients according to their estimated risk and select the best treatment strategy.
Materials And Methods: Consecutive patients undergoing liver resection for HCC on cirrhosis between 1-2015 and 12-2020 at 10 international Institutions were enrolled and their pre-operative CT scans were evaluated for the presence of spontaneous portosystemic shunts (SPSS) to identify predictors of PHLF and develop a nomogram.
BMC Gastroenterol
October 2024
Department of Gastroenterology and Hepatology, Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
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