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| http://dx.doi.org/10.1038/nmeth0907-679 | DOI Listing |
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Estimation of Genetic Parameters and GWAS on Water Efficiency Traits in the Senepol Cattle.
J Anim Breed Genet
December 2024
Departament of Animal Science, Federal University of Viçosa, Viçosa, Brazil.
The need for producing in environmentally resilient system drives new research to achieve sustainable beef production. Water footprint of the beef supply chain is a concern that must be addressed, aiming to improve water use within the production chain. One approach is genetic selection of beef cattle for water efficiency.
View Article and Find Full Text PDFGenetic Causality of Hypothyroidism and Adverse Pregnancy Outcomes: A Combined Mendelian Randomisation Study and Bioinformatics Analysis.
Int J Womens Health
December 2024
College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People's Republic of China.
Background: Observational studies have shown that hypothyroidism is strongly associated with adverse pregnancy outcomes, and that thyroxine during pregnancy comes mainly from the mother; therefore, thyroid defects in women may lead to problems such as miscarriage due to hormonal instability in early pregnancy, and foetal neurological deficits in mid- to late gestation, but whether there is a genetic causality between the two is still a matter of some controversy.
Objective: Goal to investigate the possible causal association between hypothyroidism and unfavorable pregnancy outcomes through the use of bioinformatics and Mendelian randomization (MR).
Methods: We used Mendelian randomization (MR) analyses using single nucleotide polymorphism (SNP) sites as instrumental variables to infer causal associations between exposures and outcomes.
Six genetic variants are associated with cardiovascular disease independently from canonical risk factors: a new method to refine GWAS results based on the UKBiobank phenotype database.
Mol Genet Genomics
December 2024
Department of Health Promotion, Maternal and Child Care, Internal Medicine and Medical Specialities "G. D'Alessandro" (PROMISE), University of Palermo, Via del Vespro 129, Palermo, 90127, Italy.
This paper describes a novel methodology based on GWAS filtering, aimed to find novel phenotypes associated to genetic loci independently of canonical risk factors using the large database of UK Biobank. Genome wide association studies (GWAS) is an untargeted methodology able to identify novel gene variants associated with diseases. Novel gene-phenotype associations might be discovered by this method.
View Article and Find Full Text PDFLinking ambient air pollution to mental health: evidence based on the two-sample Mendelian randomization and colocalization study.
Transl Psychiatry
December 2024
Mental health center and laboratory of psychiatry, West China Hospital, Sichuan University, Chengdu, China.
Growing evidence links air pollution, a ubiquitous environmental stressor, to a higher risk of developing mental disorders, raising significant public health concerns. Mental disorders represent a significant global public health challenge which can have a profound impact on individual lives. In this study, we used Mendelian randomization (MR) to investigate the causal relationship between ambient air pollution and four common mental disorders.
View Article and Find Full Text PDFChanges in allele frequencies and genetic architecture due to selection in two pig populations.
Genet Sel Evol
December 2024
Animal Breeding and Genomics, Wageningen University & Research, 6700 AH, Wageningen, The Netherlands.
Background: Genetic selection improves a population by increasing the frequency of favorable alleles. Understanding and monitoring allele frequency changes is, therefore, important to obtain more insight into the long-term effects of selection. This study aimed to investigate changes in allele frequencies and in results of genome-wide association studies (GWAS), and how those two are related to each other.
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