Patient doses in paediatric and adult CT examinations were investigated for modern multislice CT scanners by using specially constructed in-phantom dose measuring systems. The systems were composed of 32 photodiode dosemeters embedded in various tissue and organ sites within anthropomorphic phantoms representing the bodies of 6-year-old children and adults. Organ and the effective doses were evaluated from dose values measured at these sites. In chest CT examinations, organ doses for organs within the scanning area were 2-21 mGy for children and 7-26 mGy for adults. Thyroid doses for children were frequently the highest with a maximum of 21 mGy. In abdominal CT examinations, organ doses for organs within the scanning area were 3-16 mGy for children and 10-34 mGy for adults. Effective doses evaluated for children and adults were found to be proportional to the effective mAs of CT scanners, where linear coefficients were specific to the types of CT examinations and to the manufacturers of CT scanners. Effective doses in paediatric chest CT and abdominal CT examinations were lower than those in adult examinations by a factor of two or greater on average for the same CT scanners because of the lower effective mAs adopted in paediatric examinations.
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http://dx.doi.org/10.1259/bjr/97260522 | DOI Listing |
Indian J Pediatr
January 2025
Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Objectives: To compare six doses of intrapleural streptokinase (SK) vs. the conventional three doses in children with empyema.
Methods: In this randomized controlled trial, children with empyema received intrapleural streptokinase, either twice daily for 3 d (total 6 doses); or once daily for 3 d (total 3 doses).
Pediatr Radiol
January 2025
Department of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA.
Background: Optimization of localizer radiograph and bolus tracking doses is necessary, as their dose proportion may increase with a decreasing diagnostic scan dose in pediatric cardiothoracic computed tomography (CT).
Objective: To evaluate the radiation dose proportions of the localizer radiograph and bolus tracking in low-dose pediatric cardiothoracic CT.
Materials And Methods: For low-dose pediatric cardiothoracic CT, a posteroanterior localizer radiograph was acquired with 80 kV, and 35 mA or 20 mA in 852 infants (age<1 year).
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Pesticides can adversely affect reproduction by causing congenital abnormalities, fetal demise, and infertility. The reproductive toxicity of coragen, a modified ryanodine receptor-targeting insecticide with chlorantraniliprole concentrations of 20%, was examined in male rats. Twenty-one healthy male rats were randomly assigned to one of three groups: the control group, two orally administered with low (500 mg/kg) and high (1000 mg/kg) doses of coragen for 8 weeks.
View Article and Find Full Text PDFHealth Phys
January 2025
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, China.
The effects of different radiation doses on T and B lymphocyte functional subsets and the changes of immune cells and immune molecules were observed in mice at different times post-irradiation to provide a theoretical basis for the changes of immune cells affected by radiation. In this study, the changes of T and B immune cells and immune-related molecules were observed at 1, 3, 7, 14, and 21 d after single irradiation of 2 Gy, 4 Gy, and 6 Gy. The results showed that white blood cells (WBC), lymphocytes (LYMPH), and lymphocyte percentage (LYMPH%) in peripheral blood of mice were significantly reduced and reached the lowest point 3 d after irradiation.
View Article and Find Full Text PDFClin Pharmacol Drug Dev
January 2025
Protagonist Therapeutics, Inc., Newark, CA, USA.
Rusfertide, a peptide hepcidin mimetic, has shown efficacy in polycythemia vera. This trial investigated the multiple-dose pharmacokinetics, pharmacodynamics, and safety of once-weekly rusfertide 60 mg for 5 weeks in healthy subjects. Subjects were randomized to subcutaneous injection in the abdomen, upper arm, or thigh.
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