We report clinical and neurophysiological data of a 58 year-old man with vitamin B12 deficiency and a 6 years follow-up. The initial clinical disorders did not permit a clear distinction between peripheral and central nervous system disease. Detailed analysis of the somatosensory central conduction time (measured from onset latencies of N11 and N20) showed clear evidence of slowed down conduction at spinal cervical level (reflected by the N11-P14 interval) whereas supraspinal conduction (as shown by the P14-N20 interval) was normal. The patient's condition improved under treatment, and the somatosensory central conduction time was progressively shortened. After 6 years of treatment, the neurological examination and the somatosensory central conduction interval were normal. However, analysis of the spinal conduction still showed slowed down conduction.
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