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To drain or not to drain in minimal invasive ventral hernia surgery.
Langenbecks Arch Surg
March 2025
Carl-Von-Ossietzky University Oldenburg, Ammerländer Heerstraße 114-118, 26129, Oldenburg, Germany.
Purpose: Despite the high prevalence of ventral hernias worldwide, intraoperative drain placement remains a controversial topic. The benefit in reducing postoperative complications has not yet been clearly demonstrated. This study investigates whether a drain prevents postoperative complications after minimally invasive ventral hernia repair using the extended-totally-extraperitoneal-(eTEP)-technique.
View Article and Find Full Text PDFEffects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed with PET Imaging and Neuronally Derived Exosomes.
Biol Psychiatry
March 2025
Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC; Center for Addiction Research, Wake Forest University School of Medicine, Winston-Salem, NC; Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC. Electronic address:
Background: The present study utilized PET imaging to examine how long-term cocaine self-administration (SA) and time-off from cocaine affected kappa opioid receptor (KOR) availability in the brain of previously cocaine-naïve monkeys. In addition, neuronally derived small extracellular vesicles (NDEs) were measured from plasma to identify peripheral measures of KORs.
Methods: Female (n=6) and male (n=7) cynomolgus monkeys, living in stable same-sex social groups, were trained to SA intravenous cocaine.
Circadian rhythmicity of symptomatic phenotypes in multiple sclerosis: the CircaMS study protocol and feasibility of biomarker collection.
BMJ Open
March 2025
Department of Biomedical & Molecular Sciences, Queen's University, Kingston, Ontario, Canada
Introduction: Multiple sclerosis (MS) is a chronic autoimmune neurological disease with a variable prognosis and unpredictable course. Fatigue, pain and low mood are common symptoms that tend to fluctuate in people with MS (pwMS). Disrupted circadian rhythms may have a role in the symptoms' variability.
View Article and Find Full Text PDFIntroduction: Oral semaglutide, a glucagon-like peptide 1 receptor agonist, requires administration on an empty stomach with up to 120 mL of water, followed by no intake of food, beverages, or other oral medications for at least 30 min to ensure optimal absorption. These instructions can be challenging to adhere to during Ramadan when patients fast for extended periods. The O-SEMA-FAST study assessed the impact of fasting on adherence to oral semaglutide dosing instructions and its subsequent effects on glycaemic control and body weight.
View Article and Find Full Text PDFmodulation of proinflammatory and proteolytic activities of by selected lactobacilli.
J Oral Microbiol
February 2025
Oral Ecology Research Group (GREB), Faculty of Dental Medicine, Université Laval, Québec, QC, Canada.
Objective: The aim of the present study was to characterize the antimicrobial and anti-inflammatory activities of postbiotics from lactic acid bacteria against .
Material And Methods: The anti- activity of postbiotics from the CERELA culture collection was assessed by measuring changes in the expression of key host proteins by ELISA and qPCR, the proteolytic activity by a fluorescence and a spectrophotometric method and virulence factors from by qPCR.
Results: Even though CRL1522 and CRL1363 exhibit only a discrete antibacterial activity against , the cell-free supernatants of these strains significantly reduced -induced secretion of interleukins IL-6 and IL-8 by keratinocytes and TNF-α and IL-6 by U937 macrophage-like cells.
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