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Matched Unrelated Donor Hematopoietic Cell Transplantation: Increased Usage and Improvements in Clinical Outcomes in Canada.
Curr Oncol
December 2024
CancerCare Manitoba, University of Manitoba, Winnipeg, MB R3E 0V9, Canada.
In allogeneic hematopoietic cell transplantation (HCT), a minority of patients have access to a suitable human leukocyte antigen (HLA)-matched related donor (MRD). To fill this gap, matched unrelated donors (MUDs) are an increasingly selected donor source. Usage and outcomes after MUD HCT for Canada are not described.
View Article and Find Full Text PDFTargeting VMPFC-amygdala circuit with TMS in substance use disorder: A mechanistic framework.
Addict Biol
January 2025
Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota, USA.
The ventromedial prefrontal cortex (VMPFC), located along the medial aspect of the frontal area, plays a critical role in regulating arousal/emotions. Its intricate connections with subcortical structures, including the striatum and amygdala, highlight the VMPFC's importance in the neurocircuitry of addiction. Due to these features, the VMPFC is considered a promising target for transcranial magnetic stimulation (TMS) in substance use disorders (SUD).
View Article and Find Full Text PDFTherapeutic targeting of neuroinflammation in methamphetamine use disorder.
Future Med Chem
January 2025
Centre for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Methamphetamine (METH) is a highly addictive illicit psychostimulant with a significant annual fatality rate. Emerging studies highlight its role in neuroinflammation and a range of neurological disorders. This review examines the current landscape of potential drug targets for managing neuroinflammation in METH use disorders (MUDs), with a particular focus on the rationale behind targeting Toll-like receptor 4 (TLR4), the NLR family pyrin domain containing 3 (NLRP3) inflammasome, and other promising targets.
View Article and Find Full Text PDF[Professor Stanislav Iosofatovich Zalesky - founder of hydrogeochemical and balneological study of natural resources of Siberia].
Vopr Kurortol Fizioter Lech Fiz Kult
December 2024
Siberian State Medical University, Tomsk, Russia.
Stanislav Iosofatovich Zalesky - the first head of the Department of General Medical Chemistry of the Imperial Tomsk University (currently the Department of Chemistry of the Siberian State Medical University), a versatile scientist and public figure, acknowledged expert in medical, chemical, hydrogeological and balneological sciences. Professor S.I.
View Article and Find Full Text PDFCharacterization by 16S Amplicon Sequencing of Bacterial Communities Overall and During the Maturation Process of Peloids in Two Spas of an Italian Thermal Complex.
Microb Ecol
December 2024
Department of Biomedical, Metabolic and Neural Sciences, Section of Public Health, University of Modena and Reggio Emilia, Via Campi 287, 41125, Modena, Italy.
Peloids are made by mixing clay materials with thermo-mineral waters, enriched with organic substances from microorganisms during maturation. Their beneficial properties may depend on clay minerals, water characteristics, and microbial components, although strong evidence is lacking. Next Generation Sequencing (NGS) allows a comprehensive approach to studying the entire microbial community, including cultivable and uncultivable bacteria.
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