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Self-inflicted oral-dental mutilations (SIODMs) in paediatric patients: a systematic review of case reports and case series.
Eur J Paediatr Dent
January 2025
Dentistry Unit, AORN Santobono-Pausilipon Pediatric Hospital, 80129 Naples, Italy.
Aim: Self-inflicted oral-dental mutilations (SIODMs) are the result of an intentional or unintentional action that leads to anatomical and functional damage to the soft and hard tissues of the oral cavity. In paediatric patients they can be associated with both organic and functional diseases. A systematic review was conducted aiming to consolidate and integrate the existing knowledge on SIODM in paediatric patients.
View Article and Find Full Text PDFUnveiling urinary extracellular vesicle mRNA signature for early diagnosis and prognosis of bladder cancer.
Theranostics
January 2025
State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China.
Bladder cancer (BC) ranks as one of the most prevalent cancers. Its early diagnosis is clinically essential but remains challenging due to the lack of reliable biomarkers. Extracellular vesicles (EVs) carry abundant biological cargoes from parental cells, rendering them as promising cancer biomarkers.
View Article and Find Full Text PDFKnoevenagel-IMHDA and -IMSDA sequences for the synthesis of chiral condensed O,N-, S,N- and N-heterocycles.
RSC Adv
January 2025
Department of Organic Chemistry, University of Debrecen Egyetem Square 1 Debrecen 4032 Hungary
Domino Knoevenagel-cyclization reactions of styrene substrates, containing an -(-formyl)aryl subunit, were carried out with -substituted 2-cyanoacetamides to prepare tetrahydro-4-pyrano[3,4-]quinolone and hexahydrobenzo[]phenanthridine derivatives by competing IMHDA and IMSDA cyclization, respectively. The diastereoselective IMHDA step with α,β-unsaturated amide, thioamide, ester and ketone subunits as a heterodiene produced condensed chiral tetrahydropyran or thiopyran derivatives, which in the case of Meldrum's acid were reacted further with amine nucleophiles in a multistep domino sequence. In order to simplify the benzene-condensed tricyclic core of the targets and get access to hexahydro-1-pyrano[3,4-]pyridine derivatives, a truncated substrate was reacted with cyclic and acyclic active methylene reagents in diastereoselective Knoevenagel-IMHDA reactions to prepare novel condensed heterocyclic scaffolds.
View Article and Find Full Text PDFPromoter engineering with programmable upstream activating sequences in Aspergillus Niger cell factory.
Microb Cell Fact
January 2025
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Background: Aspergillus niger is an important industrial filamentous fungus used to produce organic acids and enzymes. A wide dynamic range of promoters, particularly strong promoters, are required for fine-tuning the regulation of gene expression to balance metabolic flux and achieve the high yields of desired products. However, the limited understanding of promoter architectures and activities restricts the efficient transcription regulation of targets in strain engineering in A.
View Article and Find Full Text PDFSustainable decentralized food waste composting using a pulse alternating ventilation pilot-scale device: Case study based on LCA and LCC analysis.
Bioresour Technol
January 2025
Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Environmental Resource Sciences, Zhejiang University, Hangzhou, China; College of Environmental & Resource Sciences, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Key Laboratory for Water Pollution Control and Environmental Safety, Hangzhou, China. Electronic address:
Currently few efficient decentralized composting reactors have been developed, and there is also little exploration into their comprehensive environmental impact and carbon emissions. This study developed a continuous pulse alternating ventilation composting pilot device, SC-PAVCR. Results demonstrated that SC-PAVCR effectively maintained the thermophilic phase during the 120-day operation period.
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