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Microwave-assisted extraction, separation, and chromogenic detection of laced marijuana for presumptive point-of-interdiction testing.
Lab Chip
September 2024
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA.
Presumptive drug screening enables timely procurement of search and arrest warrants and represents a crucial first step in crime scene analysis. Screening also reduces the burden on forensic laboratories which often face insurmountable backlogs. In most scenarios, on-site presumptive drug screening relies on chemical field tests for initial identification.
View Article and Find Full Text PDFSystemic effect of TiO micro- and nanoparticles after acute exposure in a murine model.
J Biomed Mater Res B Appl Biomater
July 2022
Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Anatomía Patológica, Buenos Aires, Argentina.
The surface of a biomedical implant can be a potential endogenous source of release of microparticles (MPs) and nanoparticles (NPs) into the biological environment. In addition, titanium particles from exogenous sources can enter the body through inhalation, ingestion, or dermal contact. The aim of this work was to evaluate the biological response of the lung, liver, and kidneys to acute exposure to titanium dioxide (TiO ).
View Article and Find Full Text PDFMicro-topography and reactivity of implant surfaces: an in vitro study in simulated body fluid (SBF).
Microsc Microanal
February 2015
1Department of Biomedical and NeuroMotor Sciences, University of Bologna - Via San Vitale 59 - 40126,Bologna,Italy.
The creation of micro-textured dental implant surfaces possessing a stimulating activity represents a challenge in implant dentistry; particularly, the formation of a thin, biologically active, calcium-phosphate layer on their surface could help to strengthen the bond to the surrounding bone. The aim of the present study was to characterize in terms of macrostructure, micro-topography and reactivity in simulated body fluid (SBF), the surface of titanium (Ti) implants blasted with TiO2 particles, acid etched with hydrofluoric acid, and activated with Ca and Mg-containing nanoparticles. Sandblasted and acid-etched implants were analyzed by ESEM-EDX (environmental scanning electron microscope with energy dispersive X-ray system) to study the micromorphology of the surface and to perform elemental X-ray microanalysis (microchemical analyses) and element mapping.
View Article and Find Full Text PDF[DLys(6)]-luteinizing hormone releasing hormone-curcumin conjugate inhibits pancreatic cancer cell growth in vitro and in vivo.
Int J Cancer
October 2011
William Hansel Cancer Prevention Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Pancreatic ductal adenocarcinomas are invariably lethal, and developing effective treatments that have minimal side effects is a challenge. Previous studies from our laboratory have shown that conjugates of cell membrane disrupting lytic peptides and luteinizing hormone releasing hormone (LHRH) target and destroy human prostate and breast cancer cells in xenografts in the nude mouse model (Hansel et al., Mol Cell Endocrinol 2007;260-262:183-9; Hansel et al.
View Article and Find Full Text PDFBiocompatibility and bone mineralization potential of 45S5 Bioglass-derived glass-ceramic scaffolds in chick embryos.
Acta Biomater
January 2009
Research Laboratory, National Atomic Energy Commission (CNEA-Reg. Noroeste), Salta A4408FTV, Argentina.
The aim of the present study was to evaluate the biocompatibility and bone mineralization potential of 45S5 Bioglass-derived glass-ceramic scaffolds using a chick embryo shell-less (ex ovo) culture system. Chick embryos were divided into two groups: control (C) and experimental (E). Scaffolds were placed on the chorioallantoic membrane (CAM) in embryos of group E at 10 days of total incubation.
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