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Rates and Predictors of Malignancy in Bethesda III and IV Thyroid Nodules: A Prospective Study.
Cureus
December 2024
Internal Medicine, University of Alexandria, Alexandria, EGY.
Aim: Thyroid nodules, based on high-resolution ultrasonography (HRUS), are among the most common endocrine abnormalities that affect the general population because of their high estimated prevalence rates. Fine needle aspiration cytology (FNAC) is a safe, cost-effective modality to differentiate between benign and malignant thyroid nodules based on the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), thus avoiding unnecessary surgery. However, categories III and IV of BSRTC remain a controversial issue in clinical practice, encompassing a wide range of risks of malignancy.
View Article and Find Full Text PDFBaseline tumour vessel perfusion as a non-invasive predictive biomarker for immune checkpoint therapy in non-small-cell lung cancer.
BMJ Oncol
August 2024
Cyrus Tang Medical Institute, State Key Laboratory of Radiation Medicine and Prevention, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu, China.
Objective: Current biomarkers for predicting immunotherapy response in non-small-cell lung cancer (NSCLC) are derived from invasive procedures with limited predictive accuracy. Thus, identifying a non-invasive predictive biomarker would improve patient stratification and precision immunotherapy.
Methods And Analysis: In this retrospective multicohort study, the discovery cohort included 205 NSCLC patients screened from ORIENT-11 and an external validation (EV) cohort included 99 real-world NSCLC patients.
Postprogression therapy and confounding for the estimated treatment effect on overall survival in phase III oncology trials.
BMJ Oncol
April 2024
Department of Gastrointestinal Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Objective: Estimations of the treatment effect on overall survival (OS) may be influenced by post-progression therapies (PPTs). It is unclear how often OS analyses account for PPT effects. The purpose of this cross-sectional analysis was to determine the prevalence of OS analyses accounting for PPT effects in phase III oncology trials.
View Article and Find Full Text PDFAgreement of zero-heat-flux thermometry compared with infrared tympanic temperature monitoring in adults undergoing major surgery.
Eur J Med Res
January 2025
Department of Otolaryngology, Affiliated Hospital of Hebei University, 212th Yuhua Road, Baoding, Hebei, China.
The patient's body temperature significantly fluctuates, affected by factors, including anesthesia. The ideal temperature monitoring method that is suitable for perioperative application is of great significance for identifying hypothermia and malignant hyperthermia early, as well as for guiding intraoperative temperature protection. This study aims to compare the cutaneous zero-heat-flux (ZHF) thermometer application in general anesthesia using the infrared tympanic measurement as a reference.
View Article and Find Full Text PDFData-driven modeling of background radiation structure utilizing matrix profile in nuclear security.
Sci Rep
January 2025
Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, TX, 78249, USA.
The inherently stochastic nature of radiation emissions makes modeling background radiation structure a particularly challenging research area. In source identification scenarios, which are critical to nuclear security, the complexity of background radiation modeling is intensified by dynamically changing factors that influence radiation measurements. Consequently, accurately modeling and estimating background radiation can significantly improve our nuclear security capabilities by enhancing the detection of anomalies within radiation data.
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