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Social Health and Serious Mental Illness-A Step Forward?
JAMA Psychiatry
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ESRC Centre for Society and Mental Health, King's College London, London, United Kingdom.
PeptideForest: Semisupervised Machine Learning Integrating Multiple Search Engines for Peptide Identification.
J Proteome Res
January 2025
Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg, Germany.
The first step in bottom-up proteomics is the assignment of measured fragmentation mass spectra to peptide sequences, also known as peptide spectrum matches. In recent years novel algorithms have pushed the assignment to new heights; unfortunately, different algorithms come with different strengths and weaknesses and choosing the appropriate algorithm poses a challenge for the user. Here we introduce PeptideForest, a semisupervised machine learning approach that integrates the assignments of multiple algorithms to train a random forest classifier to alleviate that issue.
View Article and Find Full Text PDFRecommendations for reporting and evaluating proton therapy beyond dose and constant relative biological effectiveness.
Phys Imaging Radiat Oncol
January 2025
Center for Proton Therapy, Paul Scherrer Institute, Villigen PSI, Switzerland.
Background And Purpose: In proton therapy, a relative biological effectiveness (RBE) of 1.1 is used to convert proton dose into an equivalent photon dose. However, RBE varies with tissue type, fraction dose, and beam quality parameters beyond dose such as linear energy transfer (LET) raising concerns about increased local effectiveness and potential toxicity.
View Article and Find Full Text PDFAssociation between the use of mobile touchscreen devices and the quality of parent-child interaction in preschoolers.
Front Child Adolesc Psychiatry
March 2024
Department of Ethology, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.
The early use of mobile touchscreen devices (MTSDs), including smartphones and tablets, may reduce the frequency and quality of social interactions between children and parents, which could impact their relationship and have negative consequences on children's socio-cognitive development. In this study, we applied a parental questionnaire and a behavioral observational method in a laboratory setting (free and structured play sessions) to examine the association between preschool MTSD use and the quantity and quality of parent-child relationships. Our findings revealed that preschoolers who regularly use MTSDs ( = 47, aged 4-7 years, engaging in MTSD use for at least 2 h per week) are spending less time with their parents and exhibited lower quality interactions compared to non-users ( = 25).
View Article and Find Full Text PDFEffects of digital and non-digital parental distraction on parent-child interaction and communication.
Front Child Adolesc Psychiatry
May 2024
Faculty of Social Work (HETSL | HESSO), University of Applied Sciences and Arts Western Switzerland, Lausanne, Switzerland.
Technoference, namely parental screen use in the presence of a child, is a widespread phenomenon that has negative effects on parent-child interaction and communication. When parents use screens around their children there are fewer interactions and parents are less contingent and responsive to the child. Additionally, children show more negative behaviors, such as whining, frustration, and outbursts.
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