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Prophylactic vs therapeutic blood transfusions impact on pregnant sickle cell patients.
Pak J Med Sci
January 2025
Khalid Khalil Security Forces Hospital Makkah, Makkah, Saudi Arabia.
Objective: To observe the fetomaternal outcome of therapeutic versus prophylactic blood transfusions in patients with sickle cell disease (SCD) during pregnancy.
Method: This single-center retrospective observational study was conducted on consecutive pregnant women with SCD between January 2018 and December 2020. All the pregnant women with SCD were included in this study.
Comparative ovarian morphophysiology of rats and Zebrafish after exposure to nandrolone decanoate.
Anim Reprod
January 2025
Programa de Pós-graduação em Biotecnologia - PPGBiotec, Universidade Federal do Delta do Parnaíba - UFDPar, Parnaíba, PI, Brasil.
This study aimed to compare the effects of nandrolone decanoate on the morphology and physiology of ovarian tissues in two experimental models, Zebrafish and rats, after in vitro cultivation. A total of 136 animals were used ( rats, n=36, and Zebrafish, n=100). In both experiments, the animals were divided into two groups (Control and Deca) and were exposed to nandrolone decanoate for seven weeks.
View Article and Find Full Text PDFAn Comparative Analysis of Pain Perception in Children Following Lidocaine Gel, Clove Oil, and Precooling for Intraoral Injections: A Pilot Study.
Int J Clin Pediatr Dent
December 2024
Department of Pediatric and Preventive Dentistry, Vinayaka Mission's Sankarachariyar Dental College, Vinayaka Mission's Research Foundation (Deemed to be University), Salem, Tamil Nadu, India.
Background: Dental anxiety about injections are common challenge in pediatric dentistry, often leading to delayed dental treatment.
Aim: The aim of the study was to evaluate the anesthetic effectiveness of three different topical agents in pediatric dental procedures.
Settings And Design: The study was a cross-sectional study carried out in the department of pediatric and preventive dentistry.
Synthetic studies of the mutant proinsulin syndrome demonstrate correlation between folding efficiency and age of diabetes onset.
Int J Pept Res Ther
January 2025
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, United States 46202.
Purpose: Heterozygous mutations in the insulin gene can give rise to a monogenic diabetes syndrome due to toxic misfolding of the variant proinsulin in the endoplasmic reticulum (ER) of pancreatic β-cells. Clinical mutations are widely distributed in the sequence (86 amino acids). Misfolding induces chronic ER stress and interferes in with wildtype biosynthesis and secretion.
View Article and Find Full Text PDFDevelopment of a new data management system for the study of the gut microbiome of children who are small for their gestational age.
Comput Struct Biotechnol J
December 2024
Institute of Bioinformatics, University of Münster, Münster, Germany.
Microbiome studies aim to answer the following questions: which organisms are in the sample and what is their impact on the patient or the environment? To answer these questions, investigators have to perform comparative analyses on their classified sequences based on the collected metadata, such as treatment, condition of the patient, or the environment. The integrity of sequences, classifications, and metadata is paramount for the success of such studies. Still, the area of data management for the preliminary study results appears to be neglected.
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