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Drug Development.
Alzheimers Dement
December 2024
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Background: Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder with limited treatment options. As it progresses, synapse degeneration is the most important feature contributing to cognitive dysfunction. Mitochondria supply synapses with ATP for neurotransmitter release and vesicle recycling and buffer calcium concentrations.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Background: Responses to individualized music in people living with dementia can be indicated by both verbal and non-verbal cues. Evidence suggests that elevated pupil dilation responses to familiar vs. unfamiliar music are preserved in people living with typical Alzheimer's disease (tAD), and to an extent in people with its atypical 'visual' variant (Posterior Cortical Atrophy; PCA) (Brotherhood et al.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Michigan Alzheimer's Disease Center, University of Michigan, Ann Arbor, MI, USA.
Background: Care partners (CPs) of people with dementia suffer from chronic stress impacting their mental and physical health. Mindfulness Based Stress Reduction (MBSR) has been shown to reduce depressive symptoms in CPs. Mindfulness-Based Dementia Care (MBDC) is an adaptation of MBSR tailored to CPs.
View Article and Find Full Text PDFA cross-sectional survey examining Canadian veterinarians' experiences with and perceptions of canine importation.
Can Vet J
January 2025
Department of Population Medicine (Belanger, Spence, Clow) and Department of Pathobiology (Weese), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1; Ontario Ministry of Agriculture, Food and Agribusiness, 1 Stone Road West, Guelph, Ontario N1G 4Y2 (Anderson).
Background: As numbers of dogs entering Canada from abroad are increasing, it is essential to understand the scope, challenges, and risks associated with canine importation. Canadian veterinarians' collective experience with and clinical knowledge of imported dogs can provide valuable insights into this practice.
Objective: To describe Canadian veterinarians' experiences with, and perspectives of, imported dogs in clinical practice.
A Novel Competing Endogenous RNA Network Reveals Potential Mechanisms and Biomarkers of Chemoresistance in Lung Adenocarcinoma.
J Cancer
January 2025
Department of Biostatistics, School of Public Health, Harbin Medical University, Harbin 150081, China.
Platinum resistance is a common cause of chemotherapy failure in lung adenocarcinoma (LUAD). Competing endogenous RNAs (ceRNAs), which function by competitively binding to miRNAs, can influence drug response. However, the regulatory mechanisms of ceRNAs underlying chemoresistance in LUAD remain largely unknown.
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