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Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats.
Front Psychiatry
December 2024
Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
Introduction: Aggression and self-harm disproportionately occur in youths preoccupied with social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit in the brain. Ablation of 5-HT biosynthesis by tryptophan hydroxylase 2 knockout (TPH2-KO) increases aggression in rodents.
View Article and Find Full Text PDFCOVID-19 infection and later risk of sickness absence by socioeconomic status: a cohort study.
BMC Public Health
December 2024
Finnish Institute of Occupational Health, TYÖTERVEYSLAITOS, PL 18, Helsinki, 00032, Finland.
Background: The COVID-19 pandemic was a significant health risk and resulted in increased sickness absence during the pandemic. This study examines whether a history of COVID-19 infection is associated with a higher risk of subsequent sickness absence.
Methods: In this prospective cohort study, 32,124 public sector employees responded to a survey on COVID-19 infection and lifestyle factors in 2020 and were linked to sickness absence records before (2019) and after (2021-2022) the survey.
Children's cost-benefit analysis about agents who act for the greater good.
Cognition
December 2024
Department of Psychology & Neuroscience, Duke University 417 Chapel Drive, Box 90086, Durham, NC 27708, USA. Electronic address:
Acting for the greater good often involves paying a personal cost to benefit the collective. In two studies, we investigate how children (N = 184, M = 8.02 years, SD = 1.
View Article and Find Full Text PDFInvasive aspergillosis in an immunocompetent patient: A retrospective case report and review of the literature.
J Infect Dev Ctries
November 2024
Department of Neurosurgery, Shaoxing People's Hospital, Zhejiang, 312000, China.
Introduction: Invasive aspergillosis (IA) is rare in immunocompetent patients. We present the case of a 44-year-old female with IA invading the lungs, mediastinum, heart, and brain, with a disease duration of 11 years.
Case Presentation: The patient was initially diagnosed with lung aspergillosis that had invaded the mediastinum on October 8, 2008.
Turning garbage into gold: Autophagy in synaptic function.
Curr Opin Neurobiol
December 2024
Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:
Trillions of synapses in the human brain enable thought and behavior. Synaptic connections must be established and maintained, while retaining dynamic flexibility to respond to experiences. These processes require active remodeling of the synapse to control the composition and integrity of proteins and organelles.
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