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A very low carbohydrate diet improved metabolic profile in congenital generalized lipodystrophy type 4.
Endocrinol Diabetes Metab Case Rep
January 2025
Summary: A 17-year-old girl presented with recurrent attacks of acute pancreatitis, associated with severe hyperglycemia and hypertriglyceridemia, despite being on intensive insulin therapy for the last 10 years. She had severe acanthosis nigricans, generalized loss of subcutaneous fat and prominent veins over extremities. The serum levels of glucose and triglyceride did not reduce significantly, even with maximally tolerated doses of metformin (2 g), pioglitazone (45 mg) and fenofibrate (160 mg), not uncommonly seen in poor rural families in West Bengal, India.
View Article and Find Full Text PDFPrevalence of Clinical Manifestations Known to Be Associated With Insulin Resistance Among Female Medical Students of a Private College in Saudi Arabia.
Cureus
November 2024
Family and Community Medicine, Ibn Sina National College for Medical Studies, Jeddah, SAU.
Article Synopsis
- Insulin resistance is linked to various chronic diseases, highlighting a concerning trend for future health issues, particularly within the Saudi population where data is insufficient.
- A study surveyed 272 female medical students in Jeddah to assess symptoms associated with insulin resistance, measuring physical metrics and utilizing questionnaires to gather data.
- Results showed significant correlations between certain skin conditions like acanthosis nigricans and waist circumference as indicators of insulin resistance, while conditions like acne and others were not linked, alongside higher incidences of cravings and daytime sleepiness among participants.
Skin as a Reflection of Gut Health: An Overview of Dermatological Manifestations in Primary Neoplastic and Autoimmune Gastrointestinal Disorders.
Cureus
October 2024
Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.
Gastrointestinal (GI) diseases can present with several extraintestinal manifestations, and cutaneous signs and symptoms are most frequent. Although conventionally GI and skin are considered two entirely separate organ systems, they are closely correlated in origin. An increasing amount of data highlights the complex relationship between GI and dermatological conditions.
View Article and Find Full Text PDFClinical-exome sequencing unveils the genetic landscape of polycystic ovarian syndrome (PCOS) focusing on lean and obese phenotypes: implications for cost-effective diagnosis and personalized treatment.
Sci Rep
October 2024
Environmental Epigenomics Laboratory, Department of Environmental Science, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, West Bengal, 700019, India.
Article Synopsis
- Polycystic ovarian syndrome (PCOS) is a common reproductive health issue affecting women worldwide, characterized by symptoms like hormonal imbalance, weight gain, and hair loss, and it also plays a role in infertility and gynecological cancers.* -
- The condition poses challenges for diagnosis and treatment since it can occur in both obese and lean women, influenced by various factors including genetics, environment, and lifestyle, making understanding its causes complex.* -
- This study aims to explore the genetic aspects of obesity-related PCOS using advanced bioinformatics, focusing on both overweight and normal-weight individuals, with the goal of improving early diagnosis and personalized treatment strategies.*
A case series of maturity-onset diabetes of the young highlighting atypical presentations and the implications of genetic diagnosis.
Arch Endocrinol Metab
October 2024
Division of Pediatric and Adolescent Endocrinology Indira Gandhi Institute of Child Health Bengaluru India Division of Pediatric and Adolescent Endocrinology, Indira Gandhi Institute of Child Health, Bengaluru, India.
Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of monogenic diabetes characterized by onset at a young age and an autosomal dominant mode of inheritance. Notably, MODY accounts for 2%-5% of all diabetes cases, and its distinction from types 1 (T1DM) and 2 (T2DM) diabetes mellitus is often challenging. We report herein the cases of two girls and a boy who presented initially with diabetic ketoacidosis.
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