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Functional reconstruction following bilateral amputation of the manus and pes in a cat with frostbite injury.
Can Vet J
January 2025
Guardian Veterinary Centre, 5620 99th Street NW, Edmonton, Alberta T6E 1V2 (Cormillot); VCA Canada, Guardian Veterinary Centre, 5620 99th Street NW, Edmonton, Alberta T6E 1V2 (Fowler).
This case report describes metacarpophalangeal (MCP)- and metatarsophalangeal (MTP)-level amputation and reconstruction of all 4 paws of a young female domestic shorthair cat. All 4 paws, the ears, and the distal portion of the tail underwent severe frostbite injury resulting in tissue death. Following MCP and MTP amputation, weight-bearing surface reconstruction was achieved using metacarpal and metatarsal paw-pad advancement flaps.
View Article and Find Full Text PDFEnhancement of vindoline and catharanthine production in Catharanthus roseus by LED light and plasma activated water.
PLoS One
December 2024
Department of Agricultural and Food Sciences (DISTAL), University of Bologna, Bologna, Italy.
This study aimed to increase the concentrations of vindoline (VDL) and catharanthine (CAT) in Catharanthus roseus plants cultivated in an indoor farming system using artificial lighting and plasma-activated water (PAW). After a 61-days pre-treatment period under fluorescent lamps, plants were exposed to four treatments: white light (W) from the same fluorescent lamps, red light (R) from LEDs, W with PAW, and R with PAW. These combinations were evaluated at two sampling times: 45 days (T1) and 70 days (T2) after the end of pre-treatment (DAP).
View Article and Find Full Text PDFPaw pressure and gait in middle-aged client-owned cats with and without naturally-occurring musculoskeletal disease.
PLoS One
December 2024
Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.
Musculoskeletal disease (MSD) is common in ageing cats, resulting in chronic pain and mobility impairment, but diagnosis can be challenging. We hypothesised that there would be differences between cats with and without MSD in paw pressure and spatiotemporal and kinetic gait metrics. A cohort of 53 cats, aged between 7 and 10 years from the North West of the United Kingdom, underwent an orthopaedic examination and walked on a pressure sensitive walkway.
View Article and Find Full Text PDFSalicylalazine: A novel therapeutic agent targeting TLR4/NLRP3/GSDMD-mediated pyroptosis in rheumatoid arthritis.
Int Immunopharmacol
January 2025
Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Aljouf, Saudi Arabia.
Background: Joint pain and functional impairment are hallmarks of arthritis, a painful inflammatory disease. Salicylalazine (SAZ), an anti-inflammatory compound, has demonstrated promise in modulating inflammation, thereby being selected in the current study to unveil its anti-arthritic potential.
Objectives: The aim behind this study was to assess the anti-arthritic properties of salicylalazine via evaluating its impact on paw volume, arthritic scores, oxidative stress indicators, and significant inflammatory mediators.
Inula viscosa (L). Aiton leaves extract ameliorate arthritis by antioxidative and anti-inflammatory effects in formaldehyde-induced arthritis in mice.
J Ethnopharmacol
January 2025
Laboratory of Plant Biotechnology and Ethnobotany, Faculty of Nature and Life Sciences, University of Bejaia, Bejaia, 06000, Algeria.
Ethnopharmacological Relevance: Inula viscosa (L.) Aiton is a traditional medicinal plant widely distributed and used in Mediterranean countries, its leaves are prepared by maceration to treat, rheumatic pain, inflammatory diseases, diabetes, anemia and cancer.
Aim Of The Study: The present study purpose to investigate the anti-inflammatory efficacy of I.
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