Aims: To estimate the incidence of infectious syphilis in the Wellington region between 2004 and 2006, and to characterise those with infectious syphilis, in terms of demographic and risk factors, in order to inform control of the disease.
Methods: Based on information from regional laboratories, a questionnaire was sent to the requesting clinician for all individuals with positive syphilis serology between January 2004 and December 2005. The questionnaire was also used for cases of infectious syphilis seen at regional sexual health clinics in 2006. All information was recorded anonymously.
Results: 120 questionnaires were returned (67%), and 15 cases of infectious syphilis were identified (5 in 2004, 10 in 2005), including 3 cases not known to the sexual health clinics and hence not reported to the Institute of Environmental & Scientific Research (ESR). Another 15 cases of infectious syphilis were identified from sexual health clinic records in 2006 up to October. These 30 cases of infectious syphilis were predominantly men who have sex with men (MSM) (80%), and mainly born in New Zealand (83%). Few cases reported recent sex overseas, indicating local transmission, and anonymous partners were common. The annual incidence (per 100,000 population) of infectious syphilis is estimated at 1.3 in 2004, 2.6 in 2005, and 5.9 in 2006.
Conclusion: Wellington is experiencing an outbreak of infectious syphilis, principally amongst MSM, but with crossover into the heterosexual community. Efforts are being made to control this outbreak through education of clinicians, partner notification, and offering screening and education in non-medical settings to at risk groups. We call on the Ministry of Health to enhance syphilis surveillance as a matter of urgency.
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Mikrobiyol Bul
October 2024
Hacettepe University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Türkiye.
A sexually transmitted bacterium, Mycoplasma genitalium has varying rates of reported resistance to macrolide and some fluoroquinolone group antimicrobials recommended for the treatment of its infections. It is currently recommended that the treatment of these must be planned according to macrolide resistance status. The aim of this study was to determine the presence of macrolide resistance associated mutations (MRM) and fluoroquinolone resistance associated mutations (QRM) in patients infected with M.
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Defense Centers for Public Health-Aberdeen, Armed Forces Health Surveillance Division, Defense Health Agency, U.S. Department of Defense, Aberdeen, MD.
This report presents the rates of maternal syphilis among pregnant women and congenital syphilis among newborns in the Military Health System (MHS) beneficiary population from 2012 to 2022. Medical encounter data from military hospitals and clinics as well as civilian health care facilities were obtained from the Defense Medical Surveillance System (DMSS) to determine pregnancies, live births, and confirmed diagnoses of maternal and congenital syphilis. The rate of maternal syphilis in female MHS beneficiaries increased by 233% between 2012 (n=123, 66.
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Department of Epidemiology and Surveillance, Hospital Christus Muguerza Alta Especialidad, Monterrey, México.
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Institute of Dermatology, Peking Union Medical College, Chinese Academy of Medical Sciences, National Center for STD Control, Centers for Disease Control and Prevention, Nanjing, China.
Diagnosing neurosyphilis in clinical settings poses significant challenges due to the absence of highly efficient diagnostic criteria. Our objective was to enhance the existing diagnostic criteria and assess their sensitivity and specificity for identifying neurosyphilis in HIV-negative patients. We conducted a retrospective review of patient records from a cross-sectional study carried out between December 2019 and May 2023.
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Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of Miami Miller, Miami, FL 33136, USA.
Neurosyphilis-induced dementia represents a severe manifestation of tertiary syphilis, characterized by cognitive and neuropsychiatric impairments. This condition arises from the progression of syphilis to the central nervous system, where the spirochete causes damage through invasion, chronic inflammation, and neurodegeneration. The pathophysiology involves chronic inflammatory responses, direct bacterial damage, and proteinopathies.
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