AI Article Synopsis
- In patients without acute coronary syndrome (ACS), higher levels of soluble CD40 ligand (sCD40L) were linked to a lower risk of developing coronary artery disease (CAD) and experiencing cardiac events.
- The study involved 909 patients who underwent angiography, and they were categorized into three groups based on their CAD status and cardiac events within one year.
- The results indicated that non-CAD patients had significantly higher sCD40L levels compared to CAD patients, and higher sCD40L levels correlated with a reduced risk of CAD and related events, suggesting a complex role of sCD40L in heart disease development.
Article Abstract
Background: In patients with acute coronary syndrome (ACS), elevated levels of soluble CD40 ligand (sCD40L) are associated with increased risk of cardiovascular events. We evaluated sCD40L levels and future cardiovascular events in patients not experiencing ACS.
Methods: Serum sCD40L levels were measured in 909 patients undergoing angiography. A three-way matching scheme (age, gender and catheterization time period) identified 303 patients with coronary artery disease (CAD) who experienced a cardiac event within 1 year (CAD/event), 303 patients with CAD free of events (CAD/no event) and 303 patients without CAD and free of events (no CAD).
Results: Average age was 64 +/- 11 years; 74% were males. Median (+/- SE) sCD40L levels were higher for no CAD patients (335 +/- 60 pg/ml) compared to CAD (248 +/- 65 pg/ml, p = 0.01) and to CAD/event (233 +/- 63 pg/ml, p < 0.001). There was no significant difference in median sCD40L levels between CAD/no event and CAD/event patients. Higher sCD40L quartiles were associated with a significant decrease in the risk of CAD/event versus no CAD (quartile 4 versus quartile 1: odds ratio = 0.59, p = 0.03). There was a nonsignificant trend towards a decreased risk of CAD as compared to no CAD, and for CAD/event versus CAD.
Conclusions: In non-ACS patients, higher sCD40L levels were associated with a decreased risk of CAD. This novel interaction of sCD40L raises interesting questions for CAD pathogenesis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245966 | PMC |
| http://dx.doi.org/10.1159/000106683 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of CD40 (rs1883832) and CD40L (rs1126535) gene variants on laryngeal cancer susceptibility and their association with serum biomarker levels of sCD40 and sCD40L.
PLoS One
December 2024
Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Introduction: The most prevalent head and neck cancer type is laryngeal cancer. Laryngeal cancer susceptibility is increased by a combination of genetic variables and environmental factors. Genetic predispositions that influence the functioning of the immune system can affect tumor development.
View Article and Find Full Text PDFThe association of maternal COVID-19-infection during pregnancy on the neonatal immune profile and associations with later diagnosis of neurodevelopmental disorders.
Brain Behav Immun
January 2025
Department of Internal Medicine, Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA, USA; Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA; MIND Institute, University of California, Davis, CA, USA. Electronic address:
Despite the prevalence and significant concern of COVID-19 in maternal and offspring health, little is known about the impact of COVID-19 during pregnancy on newborn immunity and neurodevelopment. This study aimed to examine 1) the relationship between maternal COVID-19 during pregnancy and newborn immune profiles and investigate the 2) associations between specific newborn immune profiles and the risk of subsequent diagnosis of a neurodevelopmental disorder (NDD) among children with prenatal exposure to COVID-19. Newborn dried bloodspots (NBS) from 545 children born at Kaiser Permanente Northern California between January 2020 and September 2021 (460 [223 males, 237 females] to COVID-19-infected [COVID+] mothers; 85 [45 males, 40 females] to COVID-19-uninfected [COVID-] mothers) were used to profile newborn immune molecules via a 42-plex cytokine/chemokine assay.
View Article and Find Full Text PDFEffects of Rhaponticum carthamoides (Willd.) Iljin on endothelial dysfunction and the inflammatory response in type 2 diabetes mellitus mice.
Phytomedicine
December 2024
Department of Cardiovascular Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, PR China. Electronic address:
Background: Diabetes mellitus (DM) and its complications seriously threaten human life and health. Rhaponticum carthamoides (Willd.) Iljin (RC) is widely used to treat cardiovascular diseases.
View Article and Find Full Text PDFThe diagnostic value and validation of IL-22 combimed with sCD40L in tuberculosis pleural effusion.
BMC Immunol
October 2024
Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Shanghai Medical College, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, People's Republic of China.
Article Synopsis
- This study investigates the role of cytokines in differentiating between tuberculosis pleurisy and malignant pleurisy, analyzing the levels of 14 specific cytokines in pleural effusion samples from 158 participants.
- Results show that all cytokines tested were significantly higher in tuberculosis pleurisy than in malignant pleurisy, with specific thresholds identified for precise diagnosis.
- The combination of IL-22 and soluble CD40 ligand demonstrated the highest accuracy, achieving 94.0% sensitivity and 96.9% specificity in distinguishing between the two conditions.
Cytokine profiles and their correlation with clinical and blood parameters in rheumatoid arthritis and systemic lupus erythematosus.
Sci Rep
October 2024
Facultad de Medicina, Instituto de Genética Humana, Pontificia Universidad Javeriana, Carrera 7 # 40-62, Bogotá, Colombia.
Article Synopsis
- The study investigates the role of cytokine imbalances in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), revealing that both conditions have elevated levels of several inflammatory cytokines compared to healthy individuals.
- Specific cytokines like IL-2, MCP-1, and TNF-α show unique elevation patterns in RA and SLE, with TNF-α particularly significant in SLE patients and IL-4 linked to lupus nephritis.
- The research suggests that targeting cytokines such as CX3CL1 for RA and TNF-α for SLE could provide new therapeutic avenues, while highlighting potential cardiovascular risks associated with certain inflammatory markers.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!