AI Article Synopsis
- This study investigates esophageal mucosal blood flow in patients with gastroesophageal reflux disease (GERD) and how treatment affects it, revealing an increase in blood flow related to mucosal injury.
- Forty-one patients with GERD and six healthy controls underwent endoscopy and blood flow measurements; results showed that GERD patients had significantly higher blood flow and thicker esophageal layers compared to controls.
- After four weeks of treatment with the proton pump inhibitor lansoprazole, there was a significant decrease in esophageal blood flow, suggesting that the medication not only alleviates GERD symptoms but also helps restore normal esophageal tissue health.
Article Abstract
Background And Aim: Mucosal injury caused by gastroesophageal reflux may result in changes in esophageal mucosal blood flow. Little is known about esophageal mucosal blood flow in patients with gastroesophageal reflux disease (GERD). Here we examined esophageal mucosal blood flow and the effects of treatment in patients with GERD.
Methods: The subjects included 41 cases (21 males and 20 females, mean age 64.2 years) in whom endoscopy was warranted in patients complaining of heartburn and/or regurgitation. We also studied six normal control subjects. Patients underwent endoscopy, laser Doppler flow meter measurements, and endoscopic ultrasonography before and after treatment.
Results: Esophageal mucosal/submucosal blood flow was increased in patients with GERD compared with the control patients. The thickness of the whole esophageal wall and that of the mucosal and submucosal layers of the esophagus correlated significantly with esophageal mucosal/submucosal blood flow. The increased esophageal mucosal/submucosal blood flow significantly decreased after 4 weeks' treatment with lansoprazole, a proton pump inhibitor.
Conclusion: Our results indicated that the pathophysiology or underlying mechanisms of GERD includes increased esophageal mucosal/submucosal blood flow, which correlates with the thickness of the esophageal wall, but is reversible and responds to treatment with lansoprazole. This suggests that proton pump inhibitors can effectively treat GERD and promote histological normalization of the mucosa and submucosa in the lower esophagus.
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| http://dx.doi.org/10.1111/j.1440-1746.2007.05113.x | DOI Listing |
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