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Atomistic Simulations and Analysis of Peripheral Membrane Proteins with Model Lipid Bilayers.
Methods Mol Biol
December 2024
Chemical and Biological Engineering Department, School of Engineering and Applied Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
All-atom molecular dynamics (AAMD) is a computational technique that predicts the movement of particles based on the intermolecular forces acting on the system. It enables the study of biological systems at atomic detail, complements observations from experiments, and can help the selection of experimental targets. Here, we describe the applications of MD simulations to study the interaction between peripheral membrane proteins and lipid bilayers.
View Article and Find Full Text PDFA neuronal gene that loops the loop.
Science
December 2024
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA.
Article Synopsis
- Noncoding RNA plays a crucial role in regulating the expression of specific genes.
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- Understanding this relationship could lead to better insights into how these factors affect behavior. *
Janus-like behavior of intrinsically disordered regions in reticulophagy.
Autophagy
January 2025
School of Medicine, Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany.
Intrinsically disordered regions (IDRs) are crucial to homeostatic and organellar remodeling pathways. In reticulophagy/ER-phagy, long cytosolic IDR-containing receptors (e.g.
View Article and Find Full Text PDFOn the Use of Strong Proton Donors as a Tool for Overcoming Line Broadening in NMR: A Comment.
Magn Reson Chem
December 2024
Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece.
Article Synopsis
- High-resolution NMR (nuclear magnetic resonance) spectra are essential for studying the structure and shape of organic molecules, especially those with labile protons.
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Killer meiotic drive executed by two alternative conformations of a single protein.
Proc Natl Acad Sci U S A
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Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109.
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