Purpose: To compare the visual field results obtained by static perimetry, microperimetry and rabbit perimetry in patients suffering from dry age related macular degeneration (AMD).
Material And Methods: Fifteen eyes with dry AMD (hard or soft macula drusen and RPE disorders) were enrolled into the study. Static perimetry was performed using M2 macula program included in Octopus 101 instrument. Microperimetry was performed using macula program (14-2 threshold, 10dB) within 10 degrees of the central visual field. The fovea program within 4 degrees was used while performing rarebit perimetry.
Results: The mean sensitivity was significantly lower (p<0.001) during microperimetry (13.5 dB) comparing to static perimetry (26.7 dB). The mean deviation was significantly higher (p<0.001) during microperimetry (-6.32 dB) comparing to static perimetry (-3.11 dB). The fixation was unstable in 47% and eccentric in 40% while performing microperimetry. The median of the "mean hit rate" in rarebit perimetry was 90% (range 40-100%). The mean examination duration was 6.5 min. in static perimetry, 10.6 min. in microperimetry and 5,5 min. in rarebit perimetry (p<0.001). Sensitivity was 30%, 53% and 93% respectively.
Conclusions: The visual field defects obtained by microperimetry were more pronounced than those obtained by static perimetry. Microperimetry was the most sensitive procedure although the most time-consuming. Microperimetry enables the control of the fixation position and stability, that is not possible using the remaining methods. Rarebit perimetry revealed slight reduction of the integrity of neural architecture of the retina. Microperimetry and rarebit perimetry provide more information in regard to the visual function than static perimetry, thus are the valuable method in the diagnosis of dry AMD.
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Purpose: To describe progression of best-corrected visual acuity (BCVA), full-field stimulus thresholds (FST), and electroretinography (ERG) over 4 years in the -related Retinal Degeneration study and to assess their suitability as clinical trial endpoints.
Design: Prospective natural history study.
Participants: Participants (n = 105) with biallelic disease-causing sequence variants in USH2A and BCVA letter scores of ≥54 were included.
Materials (Basel)
January 2025
Department of Integrated Design and Tribology Systems, Faculty of Mechanics and Technology, Rzeszów University of Technology, ul. Kwiatkowskiego 4, 37-450 Stalowa Wola, Poland.
In addition to the traditional uses of plywood, such as furniture and construction, it is also widely used in areas that benefit from its special combination of strength and lightness, particularly as a construction material for the production of finishing elements of campervans and yachts. In light of the current need to reduce emissions of climate-damaging gases such as CO, the use of lightweight construction materials is very important. In recent years, hybrid structures made of carbon fibre-reinforced plastics (CFRPs) and metals have attracted much attention in many industries.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
December 2024
Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Purpose: The purpose of this study was to determine the natural history of the photoreceptor disease in a large group of pediatric patients with RHD12-associated Leber congenital amaurosis (RDH12-LCA), to estimate the changes expected over the duration of a clinical trial, and to define the relationship between the photoreceptor loss and visual dysfunction.
Methods: Forty-six patients representing 36 families were included. The great majority of patients were under the age of 18 years.
Front Neurosci
December 2024
School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
Purpose: This study evaluates differences in the visual field performance when wearing the Defocus Incorporated Multiple Segments (DIMS) spectacle lens compared to wearing a conventional single vision (SV) spectacle lens.
Methods: Twenty-one children aged 9-14 years with spherical equivalent refraction (SER) between -1.13D to -4.
Aims: To demonstrate the relationship of dependency between the thickness of the retinal nerve fiber layer and the functional sensitivity of the retina in healthy young individuals. We also secondarily investigated the relationship between refractive error and mean retinal thickness in the macula.
Material And Methods: The basic cohort contained 30 subjects with an average age of 23.
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