Among 1052 type 2 diabetics 11 patients with insulin requirement from 102 to 138 (average 123) i.u. were selected. They were only 1% of the population. Two of them (average age 49,5 years) suffered from diabetes 4 and 6 years, had BMI 26-27 kg/m2 and were free of other metabolic syndrome manifestations. Nine patients (8 women and one man) with average parameters--62 years-old, diabetes duration 15.7 years, BMI 34,7 kg/m2 suffered from metabolic syndrome and its complications such as ischemic heart disease and/or state after stroke. The attempt of treatment 7 patients with metformin (2550 mg/24h) for 3-4 months has not caused significant decrease of daily insulin requirement.
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