AI Article Synopsis
- A new spectrofluorometric method has been created to analyze a mix of dexamethasone, dexchlorpheniramine maleate, and fluphenazine hydrochloride, addressing a gap in existing literature.
- This technique uses the first and second derivatives of the ratio of emission spectra, utilizing a zero-crossing method to separate overlapping spectral data.
- The method has proven effective for determining drug concentrations in both synthetic mixtures and commercial products, demonstrating its reliability and applicability.
Article Abstract
A new spectrofluorometric method was developed for the determination of a ternary mixture of dexamethasone, dexchlorpheniramine maleate, and fluphenazine hydrochloride in dosage forms where the literature did not reveal any method for analysis of this mixture. The method was based on the use of the first and second derivatives of the ratio of the emission spectra with a zero-crossing technique. The ratio spectra were obtained by dividing the emission spectrum of the mixture by that of one of the components. The concentrations of the other components were then determined from their respective calibration graphs treated similarly. The method can resolve the spectral overlapping of the three components and was applied successfully for the determination of these drugs in synthetic mixtures and in commercial dosage forms.
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| http://dx.doi.org/10.1016/j.aca.2006.07.057 | DOI Listing |
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