Severity: Warning
Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 143
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 994
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3134
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
There are no reports in the literature investigating the biological effect of power-frequency (50/60 Hz) magnetic fields on embryonic lens development. We investigated whether power-frequency magnetic fields act as an environmental insult and induce changes in morphology or protein and/or transcription factor mRNA expression levels in developing mouse embryonic lenses. Three groups of pregnant mice were exposed to magnetic fields (50 Hz) of varying intensities (0.0, 1.5, and 4.5 mT) for 3 h per day from gestation day (GD) 0 to 18. The embryonic lenses were enucleated on GD 18. The lenses in the three groups were found to be transparent and the lens epithelial cells from the experimental groups exhibited normal ultrastructure comparable to the control. No significant differences were found among the three groups in quantity of water soluble protein (WSP), water insoluble protein (WIP), the ratio of WIP to total protein, and the mRNA expression levels of four well known developmentally regulated DNA-binding transcription factors: Pax6, Prox1, Sox1, and c-maf. We preserved one pregnant mouse per group, fed the neonatal mice until 2 weeks of age, and then found the lenses transparent. Our results did not detect any effects on the development of embryonic lenses in mice exposed to power-frequency magnetic fields.
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Source |
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http://dx.doi.org/10.1002/bem.20338 | DOI Listing |
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