AI Article Synopsis
- The study assessed how low-fat products with added plant sterols impact cholesterol levels in people with slightly high cholesterol.
- The research involved 46 participants who followed a specific diet and consumed either plant sterol products or a placebo over two 4-week periods.
- Results showed significant reductions in total cholesterol, low-density lipoprotein (LDL) cholesterol, and apolipoprotein B levels with plant sterol-enriched products, but no changes in certain inflammation markers.
Article Abstract
Background & Aims: The purpose of this study was to evaluate the effect of low-fat products enriched with plant sterols in addition to a National Cholesterol Education Program step 1 diet on serum lipids and lipoproteins.
Methods: This study was a double-blind, randomised, placebo-controlled cross-over design with a run-in period and 2 intervention periods, each lasting 4 weeks. A total of 46 mildly hypercholesterolemic subjects (age 50.6+/-9.8) completed the trial. The study products consisted of 20 g low-fat margarine (35% fat) and 250 ml low-fat milk (0.7% fat), in total delivering 2.3g plant sterols/d.
Results: Serum total and low-density lipoprotein cholesterol were significantly reduced by 5.5% (p<0.001, 95% CI: 2.5; 8.3) and 7.7% (p=0.001, 95% CI: 3.4; 11.9), respectively, by plant sterol-enriched products compared to placebo. Serum apolipoprotein B was significantly reduced by 4.6% (p<0.05, 95% CI: 1.7; 7.5), and apolipoprotein B/apolipoprotein A-I by 3.4% (p<0.05, 95% CI: 0.1; 6.6) after plant sterol intake compared to the placebo supplement.
Conclusions: A combination of low-fat margarine and milk enriched with plant sterols significantly reduced low-density lipoprotein cholesterol, apolipoprotein B and the ratio of apolipoprotein B to apolipoprotein A-I in mildly hypercholesterolemic subjects, but had no effect on C-reactive protein and lipoprotein (a) concentrations.
Sponsorship: Unilever Denmark A/S.
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| http://dx.doi.org/10.1016/j.clnu.2007.05.008 | DOI Listing |
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