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A Comparative Transcriptome and Proteome Analysis of the Molecular Mechanism Underlying Anterior to Dorsal Eye Rotation in the Celestial-Eye Goldfish ().
Int J Mol Sci
January 2025
Fisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100068, China.
Goldfish (), subjected to millennia of artificial selection and breeding, have diversified into numerous ornamental varieties, such as the celestial-eye (CE) goldfish, noted for its unique dorsal eye rotation. Previous studies have primarily focused on anatomical modifications in CE goldfish eyes, yet the molecular underpinnings of their distinctive eye orientation remain poorly understood. This study employed high-throughput transcriptome and proteome sequencing on 110-day-old full-sibling CE goldfish, which displayed either anterior or upward eye rotations.
View Article and Find Full Text PDFGlycosylation Patterns in Gut: Implications for the Development of Vector Control Strategies.
Microorganisms
January 2025
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City 04510, Mexico.
The primary mode of transmission for Chagas disease is vector-borne transmission, spread by hematophagous insects of the subfamily. In Mexico, the triatomine is particularly significant in the transmission of . This study focused on analyzing protein expression and modifications by glycosylation in different regions of the digestive tract of fifth-instar nymphs of .
View Article and Find Full Text PDFMETTL14-mediated depression of NEIL1 aggravates oxidative damage and mitochondrial dysfunction of lens epithelial cells through regulating KEAP1/NRF2 pathways.
Cell Signal
January 2025
Eye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China. Electronic address:
Abnormal base excision repair (BER) pathway and N6-methyladenosine (m6A) of RNA have been proved to be significantly related to age-related cataract (ARC) pathogenesis. However, the relationship between the Nei Endonuclease VIII-Like1 (NEIL1) gene (a representative DNA glycosylase of BER pathway) and its m6A modification remains unclear. Here, we showed that the expression of NEIL1 was decreased in the ARC anterior lens capsules and HO-stimulated SRA01/04 cells.
View Article and Find Full Text PDFPlantar sensation associates with gait instability in older adults.
J Neuroeng Rehabil
January 2025
Department of Mechanical & Aerospace Engineering, University of Florida, Gainesville, FL, USA.
Background: Advanced age brings a loss of plantar sensation, represented, for example, as higher sensation thresholds in standardized testing. This is thought to contribute to an increased risk of falls among older adults - an intuitive premise that has yet to be fully investigated, especially in the context of walking balance. The purpose of this study was to quantify the association between plantar sensation and the instability elicited by a suite of walking balance perturbations that differ in direction and context in a cohort of n = 28 older adults (73.
View Article and Find Full Text PDFFinite Element Analysis of Functionally Loaded Subperiosteal Implants Evaluated on a Realistic Model Reproducing Severe Atrophic Jaws.
Methods Protoc
January 2025
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40125 Bologna, Italy.
Implant-supported prosthetic rehabilitation for patients with severely atrophic jaws is challenging due to complex anatomical considerations and the limitations of conventional augmentation techniques. This study explores the potential of subperiosteal (juxta-osseous) implants as an alternative solution, using finite element analysis (FEA) to evaluate mechanical performance. Realistic jaw models, developed from radiographic data, are utilized to simulate various implant configurations and load scenarios.
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