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Intramural Ventricular Arrhythmias: How to Crack a Hard Nut.
Curr Cardiol Rep
December 2024
Section of Cardiac Electrophysiology, Hospital of the University of Pennsylvania, 1 Convention Avenue, Philadelphia, Pennsylvania, 19104, USA.
Article Synopsis
- * Mapping procedures, especially in regions like the left ventricular ostium and interventricular septum, are essential for pinpointing intramural arrhythmias and planning appropriate ablation strategies.
- * Advanced techniques, such as bipolar ablation or transvenous ethanol injection, may be necessary during ablation, highlighting the importance of comprehensive mapping that includes the coronary venous system.
Diversity in Acute Autoimmune Pericarditis: Nationwide Analysis of In-Hospital Outcomes and Recurrence.
JACC Asia
October 2024
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
Article Synopsis
- Acute autoimmune pericarditis (AAP) is a rare condition with varied causes, and this study aimed to understand its diagnosis and outcomes compared to acute idiopathic pericarditis (AIP).
- Out of 20,469 patients analyzed, 170 had AAP with diagnoses including systemic lupus erythematosus and rheumatoid arthritis, while 1.8% of AAP patients died during hospitalization and 8.8% experienced cardiac tamponade.
- The research found that AAP patients had a higher risk of cardiac tamponade compared to AIP patients, but both groups had similar rates of rehospitalization, highlighting the diagnostic diversity in AAP.
Quantification of autoantibodies using a luminescent profiling method in autoimmune interstitial lung disease.
Front Immunol
November 2024
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, United States.
Autoantibodies are important for the diagnosis of autoimmune interstitial lung disease (ILD). Standard immunoassays have limitations, including their qualitative nature and/or a narrow dynamic range of detection, hindering the usefulness of autoantibodies as biomarkers of disease activity. Here, the luciferase immunoprecipitation system (LIPS) was evaluated for measuring myositis-specific and other lung-related autoantibodies in 25 subjects with idiopathic inflammatory myopathies (IIM), 26 with Sjögren's disease (SjD), and 10 healthy volunteers.
View Article and Find Full Text PDFIntestinal vascular diseases misdiagnosed as Crohn disease: analysis of 13 cases.
Pathology
September 2024
Department of Gastroenterology, Zhongnan Hospital of Wuhan University, China. Electronic address:
Article Synopsis
- The study explores rare vascular diseases (Behçet disease, enterocolic lymphocytic phlebitis, idiopathic myointimal hyperplasia of mesenteric veins, and mesenteric arteriovenous dysplasia) that can cause bowel ischaemia and are often misdiagnosed as Crohn's disease due to similar symptoms and histological patterns.
- Researchers compared clinical and pathological data of 13 patients misdiagnosed with Crohn's disease and later found to have these vascular diseases against a control group of 15 patients who were correctly diagnosed with Crohn's.
- Key distinguishing features were identified: Crohn's disease showed signs like transmural inflammation and abscesses, while
Trends in New Use of Disease-Modifying Antirheumatic Drugs for Juvenile Idiopathic Arthritis Among Commercially Insured Children in the United States from 2001 to 2022.
Arthritis Rheumatol
October 2024
Rutgers University, New Brunswick, New Jersey.
Objective: The objective of this study is to describe recent trends in disease-modifying antirheumatic drug (DMARD) use for children with juvenile idiopathic arthritis (JIA) in the United States.
Methods: We used commercial claims data (2000-2022) to perform a serial cross-sectional utilization study of children aged 1 to 18 that were diagnosed with JIA. Initiations of conventional synthetic DMARDs (csDMARDs), biologic DMARDs (bDMARDs), or targeted synthetic DMARDs (tsDMARDs) were identified after a ≥12-month baseline and expressed as a percentage of all new DMARD initiations per year, by category, class, and individual agent.
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