Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2084026 | PMC |
| http://dx.doi.org/10.1136/adc.2007.119909 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Does Tobacco Smoking Affect Vaccine-Induced Immune Response? A Systematic Review and Meta-Analysis.
Vaccines (Basel)
November 2024
Department of Medical, Movement and Wellbeing Sciences, University of Naples "Parthenope", 80133 Naples, Italy.
. Causing approximately 8 million deaths each year, tobacco smoking represents a significant public health concern. Evidence shows that smoking significantly impairs antibody production and immune cell activity following vaccination.
View Article and Find Full Text PDFDisparate kinetics in immune response of two different type b conjugate vaccines: Immunogenicity and safety observations from a randomized controlled phase IV study in healthy infants and toddlers using a 2+1 schedule.
Hum Vaccin Immunother
December 2024
GSK, Wavre, Belgium.
Since the introduction of type b (Hib) conjugate vaccines, invasive Hib disease has strongly declined worldwide, yet continued control of Hib disease remains important. In Europe, currently three different hexavalent combination vaccines containing Hib conjugates are marketed. In this phase IV, single-blind, randomized, controlled, multi-country study (NCT04535037), we aimed to compare, in a 2 + 1 vaccination schedule, the immunogenicity and safety and show non-inferiority, as well as superiority, of DTPa-HBV-IPV/Hib (Ih group) versus DTaP5-HB-IPV-Hib (Va group) in terms of anti-polyribosylribitol phosphate (PRP) antibody geometric mean concentrations (GMCs) and proportion of participants reaching anti-PRP antibody concentrations greater than or equal to a threshold of 5 µg/mL.
View Article and Find Full Text PDFAustralian Aboriginal Otitis-Prone Children Produce High-Quality Serum IgG to Putative Nontypeable Vaccine Antigens at Lower Titres Compared to Non-Aboriginal Children.
Front Cell Infect Microbiol
April 2022
Wesfarmers Centre of Vaccines & Infectious Disease, Telethon Kids Institute, Perth, WA, Australia.
Background: Nontypeable (NTHi) is the most common bacterial otopathogen associated with otitis media (OM). NTHi persists in biofilms within the middle ears of children with chronic and recurrent OM. Australian Aboriginal children suffer exceptionally high rates of chronic and recurrent OM compared to non-Aboriginal children.
View Article and Find Full Text PDFSelective Capture of Anti-N-glucosylated NTHi Adhesin Peptide Antibodies by a Multivalent Dextran Conjugate.
Chembiochem
February 2022
Interdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 13, 50019, Sesto Fiorentino, Italy.
Article Synopsis
- - The study focuses on creating tentacle-like polymers that can enhance the capture of antibodies in patient sera, specifically targeting those found in multiple sclerosis (MS) patients.
- - Researchers identified a specific peptide epitope from a protein associated with a bacteria (NTHi) that MS antibodies recognize and developed a multivalent dextran conjugate to increase antibody binding.
- - The new polymer effectively captured both IgG and IgM antibodies from MS patients, demonstrating potential for selectively isolating high-affinity autoantibodies, which could improve diagnostics and treatment for autoimmune conditions.
Hyperglucosylated adhesin-derived peptides as antigenic probes in multiple sclerosis: Structure optimization and immunological evaluation.
J Pept Sci
November 2020
Laboratory of Peptide and Protein Chemistry and Biology, Department of Neurosciences, Psychology, Drug Research and Child Health-Section of Pharmaceutical Sciences and Nutraceutics, University of Florence, Sesto Fiorentino, Italy.
Article Synopsis
- - Peptides that mimic the specific parts targeted by antibodies can be useful for diagnosing and treating autoimmune diseases like multiple sclerosis (MS) by acting as antigen substitutes.
- - Research focused on synthesizing peptides derived from the Haemophilus influenzae adhesin, particularly those containing N-linked glucopyranosyl moieties, which were found crucial for strong antibody binding in certain MS patients.
- - The best-performing synthetic peptide, Ac-KAN (Glc)VTLN (Glc)TT-NH, exhibited effective binding to IgG antibodies, but its binding characteristics didn't rely on the sugar's placement or the peptide's structure in solution, indicating complexity in how these interactions occur.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!