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Article Synopsis
- Acute kidney injury (AKI) often occurs in patients with vasodilatory shock and is linked to higher mortality rates, longer hospital stays, and potential chronic kidney disease.
- A comparison of catecholamine vasopressors (like norepinephrine and epinephrine) with non-catecholamine options (like vasopressin and angiotensin II) indicated that catecholamines could worsen kidney function and recovery.
- Research showed that non-catecholamine vasopressors were associated with better renal outcomes, including lower serum creatinine levels and reduced need for kidney replacement therapy.
The Association Between Vasopressin and Adverse Kidney Outcomes in Children and Young Adults Requiring Vasopressors on Continuous Renal Replacement Therapy.
Crit Care Explor
October 2024
Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Article Synopsis
- The study investigates the impact of vasopressin versus other vasopressors (like norepinephrine and epinephrine) on kidney outcomes in children and young adults undergoing continuous renal replacement therapy (CRRT).
- Data was analyzed from a multicenter cohort including 1,016 patients under 25 years in pediatric intensive care units (PICUs) over nearly seven years.
- Results show that vasopressin use is linked to higher risks of major adverse kidney events (MAKE-90), especially when started later in the CRRT process, indicating potential negative effects on kidney health.
Droxidopa for Vasopressor Weaning in Critically Ill Patients with Persistent Hypotension: A Multicenter, Retrospective, Single-Arm Observational Study.
J Intensive Care Med
August 2024
Department of Pharmacy, Massachusetts General Hospital, Boston, USA.
Background: Persistent vasopressor requirements are a common reason for delayed liberation from the intensive care unit (ICU) and adjunct oral agents are sometimes used to hasten time to vasopressor discontinuation. We sought to describe the use of droxidopa for vasopressor weaning in critically ill patients with prolonged hypotension.
Materials And Methods: This retrospective, single-arm, observational study included adult patients admitted to an ICU at two academic centers between 06/2016-07/2023 who received droxidopa for vasopressor weaning.
An method to evaluate vasoactivity induced by hemoglobin-based oxygen carriers in resistance vessels.
Front Bioeng Biotechnol
June 2024
Academy of Military Medical Sciences, Academy of Military Science of the Chinese People's Liberation Army, Beijing, China.
Red blood cell substitutes offer a solution to the problem of blood shortage and side effects of blood transfusion. Hemoglobin-based oxygen carriers (HBOCs) are one of the promising substitutes for red blood cells. Vasoactivity, which refers to the side effect of HBOCs that causes vasoconstriction and subsequent hypertension, limits the clinical application of HBOCs.
View Article and Find Full Text PDFCardiovascular Collapse Requiring Veno-Arterial Extracorporeal Membrane Oxygenation and Lidocaine: A Case of Massive Bupropion Overdose.
Cureus
June 2024
Department of Pulmonary Critical Care, Legacy Emanuel Medical Center, Portland, USA.
Article Synopsis
- * An 18-year-old female ingested a dangerous amount of bupropion, resulting in severe health issues including status epilepticus and heart complications, requiring advanced life support measures like ECMO.
- * After receiving intensive care, including aggressive treatments for her heart issues, the patient made a full recovery and was discharged neurologically intact, highlighting the importance of quick action in bupropion overdose cases.
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